Schwering H, Zimmermann R E, Wittrin G, Kessler B
Chirurg. 1981 Jan;52(1):41-5.
The level of factor XIII circulating in the blood plasma was determined with a commercially available screening method of the Behringwerke, Marburg, Germany. In a randomized study, the blood of 76 of both sexes and different ages was analyzed before and after surgery. In most extensive laparotomies, factor XIII declined as an expression of the vascular processes during and after the operation. The same effect was demonstrated after surgical excision of stomach or of colon carcinomas. Concurrent with the factor XIII level, fibrinogen concentration was also reduced. While the replenishment of factor XIII extended over a period of several days postoperatively, the fibrinogen synthesis was increased and exceeded normal levels after 2 to 3 days. Inspite the operational activities, factor XIII was never so low that a substitution was indicated.
采用德国马尔堡贝林werke公司的一种市售筛查方法测定血浆中循环的 XIII 因子水平。在一项随机研究中，对 76 名不同年龄和性别的患者在手术前后进行了血液分析。在大多数广泛的剖腹手术中，XIII 因子下降，这是手术期间和术后血管过程的一种表现。胃或结肠癌手术切除后也显示出相同的效果。与 XIII 因子水平同时，纤维蛋白原浓度也降低。虽然 XIII 因子的补充在术后持续数天，但纤维蛋白原合成增加，并在 2 至 3 天后超过正常水平。尽管有手术操作，但 XIII 因子从未低到需要进行替代治疗的程度。
