Herter T
Neurosurgical Clinic and Polyclinic, Wilhelms University of Westfalen, Münster, West Germany.
Neurosurg Rev. 1988;11(3-4):249-58. doi: 10.1007/BF01741418.
Although the fibrin adhesion enjoys increasing success in many areas of surgery, it has not, however, become fully established in nerve anastomosis. It was in this area particularly that significant advantages were expected. As the fibrin clot dissolved prematurely, however, and dehiscences ensued, antifibrinolytic substances had to be added to the adhesive. Fibroses occurred frequently as a result, which to date encumber nerve adhesive. We examined various factors of the adhesive system for their fibrosis-inducing effect. We were able to establish that no additional fibrosis-promoting effect emanated from aprotinin and the fibrin clot as a supply barrier, whereas thrombin, Factor XIII and fibronectin possess a fibrosis-promoting effect.
尽管纤维蛋白黏合剂在许多外科手术领域取得了越来越多的成功，但在神经吻合术中尚未完全确立其地位。然而，正是在这个领域尤其期望能有显著优势。然而，由于纤维蛋白凝块过早溶解并随后出现裂开，不得不向黏合剂中添加抗纤溶物质。结果频繁发生纤维化，迄今为止这一直困扰着神经黏合剂。我们研究了黏合系统的各种因素对纤维化诱导作用的影响。我们能够确定，抑肽酶和作为供应屏障的纤维蛋白凝块不会产生额外的促纤维化作用，而凝血酶、因子 XIII 和纤连蛋白具有促纤维化作用。
