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冷冻保存的人甲状旁腺组织的自体移植(作者译)

[Autotransplantation of cryopreserved human parathyroid tissue (author's transl)].

作者信息

Wagner P K, Rothmund M, Kümmerle F, Kessler F J, Gabbert H, Krause U

出版信息

Dtsch Med Wochenschr. 1981 Mar 20;106(12):363-7. doi: 10.1055/s-2008-1070318.

Abstract

Following the third operation, aparathyroidism occurred in a 70-year-old female with primary hyperparathyroidism due to parathyroid hyperplasia. Part of the parathyroid obtained during the last operation was cryopreserved immediately after resection and replanted successfully after 15 days into the lower arm muscles. The function of the transplanted tissue was demonstrated by successful stepwise reduction of hormone substitution. Parathyroid hormone concentrations in the blood of the veins draining the transplanted tissue were more than double in comparison with the contralateral side. Functional and morphological investigations of the defrosted tissue prior to transplantation showed vitality and intact morphology.

摘要

第三次手术后,一名因甲状旁腺增生导致原发性甲状旁腺功能亢进的70岁女性发生了甲状旁腺功能减退。上次手术中获取的部分甲状旁腺在切除后立即冷冻保存,并在15天后成功移植到上臂肌肉中。通过逐步成功减少激素替代证明了移植组织的功能。引流移植组织的静脉血液中的甲状旁腺激素浓度比另一侧高出一倍多。移植前对解冻组织进行的功能和形态学研究显示其具有活力且形态完整。

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