• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Cyclic-GMP enhances light-induced excitation and induces membrane currents in Drosophila retinal photoreceptors.环磷酸鸟苷增强果蝇视网膜光感受器中光诱导的兴奋并诱导膜电流。
J Neurosci. 1995 Nov;15(11):7196-200. doi: 10.1523/JNEUROSCI.15-11-07196.1995.
2
Activation of light-dependent K+ channels in ciliary invertebrate photoreceptors involves cGMP but not the IP3/Ca2+ cascade.
Neuron. 1995 Sep;15(3):607-18. doi: 10.1016/0896-6273(95)90149-3.
3
Cyclic GMP is involved in the excitation of invertebrate photoreceptors.环鸟苷酸参与无脊椎动物光感受器的兴奋过程。
Nature. 1986;324(6096):468-70. doi: 10.1038/324468a0.
4
Tuning outer segment Ca2+ homeostasis to phototransduction in rods and cones.调节视杆细胞和视锥细胞外段Ca2+稳态以进行光转导。
Adv Exp Med Biol. 2002;514:179-203. doi: 10.1007/978-1-4615-0121-3_11.
5
Cyclic GMP increases photocurrent and light sensitivity of retinal cones.
Nature. 1985;317(6032):64-6. doi: 10.1038/317064a0.
6
On the gating mechanisms of the light-dependent conductance in Pecten hyperpolarizing photoreceptors: does light remove inactivation in voltage-dependent K channels?关于扇贝超极化光感受器中光依赖性电导的门控机制：光是否消除了电压依赖性钾通道的失活？
J Gen Physiol. 2005 May;125(5):455-64. doi: 10.1085/jgp.200509269. Epub 2005 Apr 11.
7
Putative ClC-2 chloride channel mediates inward rectification in Drosophila retinal photoreceptors.假定的ClC-2氯通道介导果蝇视网膜光感受器的内向整流。
J Membr Biol. 2005 Oct;207(3):151-60. doi: 10.1007/s00232-005-0810-3.
8
Calcium-independent, cGMP-mediated light adaptation in invertebrate ciliary photoreceptors.无脊椎动物纤毛光感受器中不依赖钙的、由环鸟苷酸介导的光适应。
J Neurosci. 2005 Feb 23;25(8):2042-9. doi: 10.1523/JNEUROSCI.5129-04.2005.
9
Inhibitors of cyclic-GMP phosphodiesterase alter excitation of Limulus ventral photoreceptors in Ca(2+)-dependent fashion.环磷酸鸟苷磷酸二酯酶抑制剂以钙依赖方式改变鲎腹侧光感受器的兴奋。
J Neurosci. 1995 Oct;15(10):6586-91. doi: 10.1523/JNEUROSCI.15-10-06586.1995.
10
Whole-cell recording of light-evoked photoreceptor responses in a slice preparation of the cuttlefish retina.在乌贼视网膜切片标本中对光诱发的光感受器反应进行全细胞记录。
Vis Neurosci. 2005 May-Jun;22(3):359-70. doi: 10.1017/S0952523805223106.

引用本文的文献

1
Melanopsin-expressing amphioxus photoreceptors transduce light via a phospholipase C signaling cascade.表达黑素蛋白的文昌鱼感光器通过磷脂酶 C 信号级联转导光信号。
PLoS One. 2012;7(1):e29813. doi: 10.1371/journal.pone.0029813. Epub 2012 Jan 3.
2
Seasonal behavior in Drosophila melanogaster requires the photoreceptors, the circadian clock, and phospholipase C.黑腹果蝇的季节性行为需要光感受器、生物钟和磷脂酶C。
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1945-50. doi: 10.1073/pnas.0308240100. Epub 2004 Feb 6.
3
Soluble guanylate cyclase is required during development for visual system function in Drosophila.在果蝇发育过程中，可溶性鸟苷酸环化酶对于视觉系统功能是必需的。
J Neurosci. 2001 Oct 1;21(19):7705-14. doi: 10.1523/JNEUROSCI.21-19-07705.2001.
4
Coordinated gating of TRP-dependent channels in rhabdomeral membranes from Drosophila retinas.果蝇视网膜横纹肌膜中TRP依赖性通道的协同门控。
J Neurosci. 2000 Oct 1;20(19):7193-8. doi: 10.1523/JNEUROSCI.20-19-07193.2000.
5
Modulation of the light response by cAMP in Drosophila photoreceptors.果蝇光感受器中cAMP对光反应的调节
J Neurosci. 1999 Oct 15;19(20):8799-807. doi: 10.1523/JNEUROSCI.19-20-08799.1999.
6
Current issues in invertebrate phototransduction. Second messengers and ion conductances.无脊椎动物光转导的当前问题。第二信使与离子电导。
Mol Neurobiol. 1997 Aug;15(1):41-63. doi: 10.1007/BF02740615.
7
Molecular and immunological characterization of a Gq protein from ventral and lateral eye of the horseshoe crab Limulus polyphemus.鲎（Limulus polyphemus）腹侧和侧眼Gq蛋白的分子与免疫特性分析
Invert Neurosci. 1996 Dec;2(3):175-82. doi: 10.1007/BF02214173.

环磷酸鸟苷增强果蝇视网膜光感受器中光诱导的兴奋并诱导膜电流。

Cyclic-GMP enhances light-induced excitation and induces membrane currents in Drosophila retinal photoreceptors.

作者信息

Bacigalupo J, Bautista D M, Brink D L, Hetzer J F, O'Day P M

机构信息

Universidad de Chile, Facultad de Ciencias, Departamento de Biologia, Santiago, Chile.

出版信息

J Neurosci. 1995 Nov;15(11):7196-200. doi: 10.1523/JNEUROSCI.15-11-07196.1995.

DOI:10.1523/JNEUROSCI.15-11-07196.1995
PMID:7472474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6578040/
Abstract

Phototransduction in the Drosophila retina appears to require the phosphoinositide signaling cascade following receptor/G-protein activation. Subsequent opening of membrane cationic channels causes excitation. The biochemical events underlying channel opening and regulation of sensitivity remain largely unknown. Evidence is mounting that phototransduction in Drosophila and other invertebrate species may additionally involve the second messenger, cyclic-GMP (cGMP). We report that exogenous cGMP influenced Drosophila retinal phototransduction in two ways. In whole cell tight-seal voltage-clamp experiments, membrane permeant cGMP analog, 8-bromo-cyclic-GMP (8-Br-cGMP), induced membrane currents and dramatically enhanced light-induced currents. The currents induced by 8-Br-cGMP possessed reversal potentials similar to those induced by light. The magnitudes of cGMP-induced currents exhibited marked dependence on intensity of background illumination. Potential direct or modulatory roles of cGMP in Drosophila phototransduction are discussed.

摘要

果蝇视网膜中的光转导似乎在受体/G蛋白激活后需要磷酸肌醇信号级联反应。随后膜阳离子通道的开放导致兴奋。通道开放和灵敏度调节背后的生化事件在很大程度上仍然未知。越来越多的证据表明，果蝇和其他无脊椎动物物种中的光转导可能还涉及第二信使环鸟苷酸（cGMP）。我们报告外源性cGMP以两种方式影响果蝇视网膜光转导。在全细胞膜片钳实验中，膜通透性cGMP类似物8-溴环鸟苷酸（8-Br-cGMP）诱导膜电流并显著增强光诱导电流。8-Br-cGMP诱导的电流具有与光诱导电流相似的反转电位。cGMP诱导电流的大小对背景光照强度表现出明显的依赖性。文中讨论了cGMP在果蝇光转导中的潜在直接或调节作用。