Berry I, Gaillard J F, Guo Z, Cordoliani Y S, Massip P, Manelfe C, Danet B
Service de Biophysique et Médecine Nucléaire, CHU Rangueil, Toulouse.
J Neuroradiol. 1995 Sep;22(3):218-28.
CT and MRI are not consistently able to differentiate central nervous system (CNS) lymphoma from focal cerebral infection such as toxoplasmosis in the human immunodeficiency virus (HIV) involvement. In this study thallium 201 (and/or technetium-MIBI) SPECT was performed in 6 patients suffering from AIDS and CNS lesions. An index based on the ratio of thallium uptake in the lesion vs the contralateral scalp was calculated. In 4 out of 5 patients with lymphoma (3 confirmed by biopsy, 2 highly suspected on CT and resistance to antitoxoplasmosis treatment) focal lesions showed high uptake of thallium. On the other hand one markedly necrotic lymphoma and all infectious lesions did not take up thallium. This suggests a role for thallium 201 brain SPECT in the workup of focal CNS lesions in AIDS.
在人类免疫缺陷病毒（HIV）感染的情况下，计算机断层扫描（CT）和磁共振成像（MRI）并不能始终如一地将中枢神经系统（CNS）淋巴瘤与局灶性脑感染（如弓形虫病）区分开来。在本研究中，对6例患有艾滋病和中枢神经系统病变的患者进行了铊201（和/或锝-甲氧基异丁基异腈）单光子发射计算机断层扫描（SPECT）。计算了基于病变部位铊摄取量与对侧头皮铊摄取量之比的指数。在5例淋巴瘤患者中的4例（3例经活检确诊，2例在CT上高度怀疑且对抗弓形虫病治疗有抵抗性），局灶性病变显示铊摄取量高。另一方面，1例明显坏死的淋巴瘤和所有感染性病变均未摄取铊。这表明铊201脑SPECT在艾滋病患者局灶性中枢神经系统病变的检查中具有一定作用。
