利用铊-201脑单光子发射计算机断层扫描（SPECT）鉴别艾滋病患者的脑淋巴瘤与弓形虫脑炎。
Use of thallium-201 brain SPECT to differentiate cerebral lymphoma from toxoplasma encephalitis in AIDS patients.
作者信息
Ruiz A, Ganz W I, Post M J, Camp A, Landy H, Mallin W, Sfakianakis G N
机构信息
Department of Diagnostic Radiology, University of Miami School of Medicine, FL 33136.
出版信息
AJNR Am J Neuroradiol. 1994 Nov;15(10):1885-94.
PURPOSE
To determine whether thallium-201 brain single-photon emission CT could be used to make the distinction between central nervous system lymphoma and toxoplasma encephalitis, which may not be possible by routine MR and CT.
METHODS
A total of 37 patients with acquired immunodeficiency syndrome who had intracranial mass lesions found during a 9-month prospective study by either MR or CT underwent further evaluation with Tl-201 brain single-photon emission CT.
RESULTS
Twelve patients had increased intense focal Tl-201 uptake. All of these patients had either biopsy- or autopsy-proven lymphoma. Twenty-five of the patients studied had no Tl-201 brain uptake in the lesion(s); 24 of these patients had toxoplasma encephalitis on clinical follow-up. One patient with no Tl-201 uptake was found by cerebrospinal fluid analysis to have mycobacterium tuberculosis abscess.
CONCLUSION
Patients with acquired immunodeficiency syndrome who have intracranial mass lesions on MR or CT may benefit from Tl-201 brain single-photon emission CT because it can help distinguish between lymphoma and infectious lesions such as toxoplasma encephalitis.
目的
确定201铊脑单光子发射计算机断层扫描（Tl-201脑SPECT）是否可用于区分中枢神经系统淋巴瘤和弓形体脑炎，而这通过常规磁共振成像（MR）和计算机断层扫描（CT）可能无法做到。
方法
在一项为期9个月的前瞻性研究中，通过MR或CT发现有颅内占位性病变的37例获得性免疫缺陷综合征患者接受了Tl-201脑SPECT进一步评估。
结果
12例患者Tl-201摄取灶性增强。所有这些患者均经活检或尸检证实为淋巴瘤。研究的25例患者病变部位无Tl-201脑摄取；这些患者中有24例在临床随访中患有弓形体脑炎。1例无Tl-201摄取的患者经脑脊液分析发现患有结核分枝杆菌脓肿。
结论
在MR或CT上有颅内占位性病变的获得性免疫缺陷综合征患者可能受益于Tl-201脑SPECT，因为它有助于区分淋巴瘤和感染性病变，如弓形体脑炎。
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