Narkewicz M R, Smith D, Silverman A, Vierling J, Sokol R J
Department of Pediatrics, University of Colorado School of Medicine, Denver, USA.
J Pediatr. 1995 Nov;127(5):815-8. doi: 10.1016/s0022-3476(95)70181-8.
Nine children aged 18 months to 17 years (mean 5.7 years) with chronic hepatitis b virus infection and chronic active hepatitis were treated with 5 to 6 million units/m2 of body surface area of interferon -alpha 2b administered subcutaneously three times per week for 4 months (n = 1) or 6 months (n = 8). At 12 months after the start of therapy, six children less than 3 years of age responded to the treatment (three completely and three partially), whereas only one of three children older than 7 years of age responded. We conclude that IFN treatment may be effective in children with chronic HBV infection, especially when administered while they are young.
9名年龄在18个月至17岁（平均5.7岁）的慢性乙型肝炎病毒感染且患有慢性活动性肝炎的儿童，接受了皮下注射α-2b干扰素治疗，剂量为每平方米体表面积500万至600万单位，每周3次，持续4个月（n = 1）或6个月（n = 8）。治疗开始后12个月时，6名3岁以下儿童对治疗有反应（3名完全缓解，3名部分缓解），而7岁以上的3名儿童中只有1名有反应。我们得出结论，干扰素治疗可能对慢性HBV感染儿童有效，尤其是在他们年幼时给药。
