使用干扰素和丙种球蛋白成功治疗非家族性噬血细胞性淋巴组织细胞增生症。
Successful treatment of non-familial haemophagocytic lymphohistiocytosis with interferon and gammaglobulin.
作者信息
Estlin E J, Palmer R D, Windebank K P, Lowry M F, Pearson A D
机构信息
Department of Child Health, Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne.
出版信息
Arch Dis Child. 1996 Nov;75(5):432-5. doi: 10.1136/adc.75.5.432.
Abstract
Two cases of non-familial haemophagocytic lymphohistiocytosis (HLH) are presented in which treatment with interferon alfa and gammaglobulin was associated with complete clinical remission. In one case, serological evidence of recent Epstein-Barr virus infection was found. Natural killer cell activity was within normal limits in both children, compatible with a secondary form of HLH. The combination of interferon alfa and intravenous gammaglobulin requires further evaluation in the treatment of non-familial HLH.
摘要
本文报告了两例非家族性噬血细胞性淋巴组织细胞增生症（HLH），这两例患者经干扰素α和丙种球蛋白治疗后实现了完全临床缓解。其中一例发现了近期感染爱泼斯坦-巴尔病毒的血清学证据。两名儿童的自然杀伤细胞活性均在正常范围内，符合继发性HLH的表现。干扰素α与静脉注射丙种球蛋白联合治疗非家族性HLH的疗效有待进一步评估。
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