Estlin E J, Palmer R D, Windebank K P, Lowry M F, Pearson A D
Department of Child Health, Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne.
Arch Dis Child. 1996 Nov;75(5):432-5. doi: 10.1136/adc.75.5.432.
Two cases of non-familial haemophagocytic lymphohistiocytosis (HLH) are presented in which treatment with interferon alfa and gammaglobulin was associated with complete clinical remission. In one case, serological evidence of recent Epstein-Barr virus infection was found. Natural killer cell activity was within normal limits in both children, compatible with a secondary form of HLH. The combination of interferon alfa and intravenous gammaglobulin requires further evaluation in the treatment of non-familial HLH.
本文报告了两例非家族性噬血细胞性淋巴组织细胞增生症（HLH），这两例患者经干扰素α和丙种球蛋白治疗后实现了完全临床缓解。其中一例发现了近期感染爱泼斯坦-巴尔病毒的血清学证据。两名儿童的自然杀伤细胞活性均在正常范围内，符合继发性HLH的表现。干扰素α与静脉注射丙种球蛋白联合治疗非家族性HLH的疗效有待进一步评估。
