[生药浴研究。II.：黄连提取物作为皮肤渗透促进剂的作用]
[Study on baths with crude drug. II.: the effects of coptidis rhizoma extracts as skin permeation enhancer].
作者信息
Namba T, Sekiya K, Toshinal A, Kadota S, Hatanaka T, Katayama K, Koizumi T
机构信息
Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University, Japan.
出版信息
Yakugaku Zasshi. 1995 Aug;115(8):618-25. doi: 10.1248/yakushi1947.115.8_618.
Skin permeation and its enhancing activity of Coptidis Rhizoma (Coptis japonica Makino) were studied in regard to its application as a bath agent. As a result, methanol extracts and three alkaloids (berberine, coptisine, and palmatine isolated from Coptidis Rhizoma) enhanced effectively the skin permeation of 5-fluorouracil, which is taken as a hydrophilic permeant. Furthermore, it was observed that diffusion coefficient is almost constant on the skin permeation of 5-fluorouracil and was also observed that these three kinds of alkaloids did not penetrate through the skin, but adsorbed into the skin. These results suggest that these three protoberberine type alkaloids increase the concentration of polar drugs in the skin and enhance the skin permeation similarly to surfactants.
就黄连（日本黄连）作为沐浴剂的应用，对其皮肤渗透作用及其增强活性进行了研究。结果表明，甲醇提取物和从黄连中分离出的三种生物碱（小檗碱、黄连碱和巴马汀）能有效增强5-氟尿嘧啶（一种亲水性渗透剂）的皮肤渗透。此外，观察到5-氟尿嘧啶皮肤渗透时扩散系数几乎恒定，还观察到这三种生物碱并未穿透皮肤，而是吸附在皮肤上。这些结果表明，这三种原小檗碱型生物碱可增加极性药物在皮肤中的浓度，并与表面活性剂类似地增强皮肤渗透。
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