Villarini M, Moretti M, Scassellati-Sforzolini G, Monarca S, Pasquini R, Crea M G, Leonardis C
Department of Hygiene, University of Perugia, Italy.
J Environ Pathol Toxicol Oncol. 1995;14(1):45-52.
The effects of the synthetic dibromo-pyrethroid insecticide deltamethrin on some hepatic phase I and II enzyme activities were studied in rat liver. The animals were treated with daily doses of 5 and 10 mg/kg of both pure insecticide or its commercial formulation (Decis), administered i.p. in corn oil for 7 days. The following enzyme activities were studied: NADPH-cytochrome-P450 reductase, aryl-hydrocarbon hydroxylase, aminopyrine N-demethylase, glutamyl cysteine synthetase, glutathione S-transferase, glutathione peroxidase, peroxisomal acyl-CoA oxidase, catalase, and urate oxidase. Both deltamethrin and its commercial formulation were effective in modifying the activities of several of these hepatic xenobiotic-metabolizing enzymes. However, some differences in enzyme modifications were found between treatment with pure or commercial deltamethrin, the latter being more active. This effect could be ascribed to additives, solvents, and chemical intermediates present in the Decis formulation. These results suggest that exposure to this deltamethrin commercial formulation could be more dangerous than exposure to deltamethrin alone, both in terms of its hepatotoxicity and/or alterations in the hepatic biotransformation of other occupational/environmental xenobiotics.
研究了合成二溴拟除虫菊酯杀虫剂溴氰菊酯对大鼠肝脏中一些肝药酶Ⅰ相和Ⅱ相酶活性的影响。给动物腹腔注射每日剂量为5和10 mg/kg的纯杀虫剂或其商业制剂（敌杀死），溶于玉米油中，持续7天。研究了以下酶活性：NADPH-细胞色素P450还原酶、芳烃羟化酶、氨基比林N-脱甲基酶、谷氨酰半胱氨酸合成酶、谷胱甘肽S-转移酶、谷胱甘肽过氧化物酶、过氧化物酶体酰基辅酶A氧化酶、过氧化氢酶和尿酸氧化酶。溴氰菊酯及其商业制剂均能有效改变这些肝外源性物质代谢酶中的几种酶的活性。然而，在使用纯溴氰菊酯或商业溴氰菊酯治疗之间发现了一些酶修饰的差异，后者更具活性。这种效应可能归因于敌杀死制剂中存在的添加剂、溶剂和化学中间体。这些结果表明，接触这种溴氰菊酯商业制剂在肝毒性和/或其他职业/环境外源性物质的肝脏生物转化改变方面可能比单独接触溴氰菊酯更危险。
