当药物的血浆处置曲线为多指数曲线时，用于计算药物清除时间和药物蓄积时间的简单近似公式。 - Suppr | 超能文献

Simple approximate formulas for calculating the time to clear drug and the time to accumulate drug when the plasma disposition curve of the drug is multiexponential.

作者信息

Noe D A

出版信息

J Pharmacokinet Biopharm. 1994 Dec;22(6):565-7. doi: 10.1007/BF02353795.

DOI:10.1007/BF02353795

Abstract

摘要

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本文引用的文献

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Compartment- and model-independent linear plateau principle of drugs during a constant-rate absorption or intravenous infusion.

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General derivation of the equation for time to reach a certain fraction of steady state.达到稳态一定分数所需时间方程的一般推导。

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Rapid compartment- and model-independent estimation of times required to attain various fractions of steady-state plasma level during multiple dosing of drugs obeying superposition principle and having various absorption or infusion kinetics.在多次给药过程中，对遵循叠加原理且具有不同吸收或输注动力学的药物，快速进行与房室和模型无关的稳态血浆水平不同分数达到所需时间的估计。

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