Nève P, Rocmans P, Ketelbant-Balasse P, Dumont J E
Ann Endocrinol (Paris). 1978;39(6):487-8.
Hyperactive dog thyroids were prepared by repeated TSH stimulation in vivo. Butanol extractable 125iodine (BE 125I) release in vitro from such hyperactive thyroid slices was enhanced when compared with resting slices. Apical pseudopods an colloid droplets were exceptional in such hyperactive thyroids. Moreover, BE125I release was intensitive to cytochalasin B, microtubules and metabolic inhibitors, and decreased only with temperature. Our data demonstrate that hormonal secretion by hyperactive thyroids is not secondary to apical phagocytosis of colloid droplets.
通过在体内反复进行促甲状腺激素刺激制备出功能亢进的犬甲状腺。与静止状态的甲状腺切片相比，这种功能亢进的甲状腺切片在体外释放的丁醇可提取碘（BE 125I）有所增加。在这种功能亢进的甲状腺中，顶端伪足和胶体小滴较为特殊。此外，BE125I的释放对细胞松弛素B、微管和代谢抑制剂敏感，且仅随温度降低。我们的数据表明，功能亢进的甲状腺激素分泌并非继发于胶体小滴的顶端吞噬作用。
