Tsai S C, Kao C H, ChangLai S P, Lan J L, Wang S J
Department of Nuclear Medicine.
Gaoxiong Yi Xue Ke Xue Za Zhi. 1995 Sep;11(9):521-7.
The alveolar epithelium permeability (AP) in 34 patients with systemic lupus erythematosus (SLE) was measured by Tc-99m DTPA radioaerosol inhalation lung scintigraphy. The degree of AP damage in SLE was represented as the slope of the time-activity curve from the dynamic lung imagings. The patients were divided into two subgroups according to the following two criteria. [A] clinical feature: they were separated as stable or flare stage; and [B] chest X-ray findings: they were separated as positive or negative results. Meanwhile, the quantitative Gallium-67 (Ga) lung scan was performed as Ga uptake index (GUI) to evaluate the severity of inflammation in the lungs in SLE. The results show that [1] there were no significant statistical differences in the degree of AP damage between the two subgroups according to clinical features or chest X-ray findings, and [2] no good correlation between the degree of AP damage and inflammation of the lungs was found. In conclusion, the change of AP in SLE may be a mechanism not related to the presentation of clinical features or chest X-ray findings, and the degree of AP damage in SLE is not related to the severity of pulmonary inflammation.
采用Tc-99m DTPA放射性气溶胶吸入肺闪烁显像法测量了34例系统性红斑狼疮（SLE）患者的肺泡上皮通透性（AP）。SLE中AP损伤程度通过动态肺显像的时间-活性曲线斜率来表示。根据以下两个标准将患者分为两个亚组。[A]临床特征：分为稳定期或活动期；[B]胸部X线检查结果：分为阳性或阴性。同时，进行定量镓-67（Ga）肺扫描作为Ga摄取指数（GUI），以评估SLE患者肺部炎症的严重程度。结果显示：[1]根据临床特征或胸部X线检查结果划分的两个亚组之间，AP损伤程度无显著统计学差异；[2]未发现AP损伤程度与肺部炎症之间存在良好相关性。总之，SLE中AP的变化可能是一种与临床特征或胸部X线检查结果表现无关的机制，且SLE中AP损伤程度与肺部炎症严重程度无关。
