Kao C H, Lin H T, Yu S L, Wang S J, Lan J L
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
Nucl Med Commun. 1994 Nov;15(11):928-31. doi: 10.1097/00006231-199411000-00012.
The severity of lung inflammation in 34 patients with systemic lupus erythematosus (SLE) was measured by quantitative 67Ga-citrate lung scanning. The severity of lung inflammation in SLE was represented by the 67Ga uptake index (GUI). Quantitative 67Ga lung scanning was also performed on 20 normal controls for comparison with the SLE patients. The patients were divided into two subgroups according to the following two criteria: (a) stable or flare stage according to clinical features; or (b) positive or negative results of chest X-ray. The GUI values of the subgroups were also compared. The results revealed a trend towards higher values of GUI in SLE patients than in the normal controls. The GUI values were also higher for SLE cases with a flare stage or a negative chest X-ray than in SLE cases with a stable stage or a positive chest X-ray. The statistical results reveal that the differences in the GUI values are not significant. However, we found that (1) positive chest X-ray findings may be a later manifestation of a lung inflammation and (2) the values of GUI parallel clinical features in SLE patients.
通过定量67镓-柠檬酸盐肺部扫描测定了34例系统性红斑狼疮（SLE）患者肺部炎症的严重程度。SLE患者肺部炎症的严重程度用67镓摄取指数（GUI）表示。还对20名正常对照者进行了定量67镓肺部扫描，以便与SLE患者进行比较。根据以下两个标准将患者分为两个亚组：（a）根据临床特征分为稳定期或活动期；或（b）胸部X线检查结果为阳性或阴性。还比较了各亚组的GUI值。结果显示，SLE患者的GUI值有高于正常对照者的趋势。活动期或胸部X线检查结果为阴性的SLE病例的GUI值也高于稳定期或胸部X线检查结果为阳性的SLE病例。统计结果显示，GUI值的差异不显著。然而，我们发现：（1）胸部X线检查阳性结果可能是肺部炎症的晚期表现；（2）SLE患者的GUI值与临床特征平行。
