Sundberg K, Bang J, Brocks V, Jensen F R, Smidt-Jensen S, Philip J
Department of Gynecology and Obstetrics, Rigshospitalet, University of Copenhagen, Denmark.
J Ultrasound Med. 1995 Aug;14(8):585-90. doi: 10.7863/jum.1995.14.8.585.
Fetal and neonatal outcome is reported for 249 consecutive low-risk pregnancies in which early amniocentesis was carried out with filter technique, at a mean gestational age of 12.5 weeks, to improve the yield in cell cultures. Three pregnancies (1.2%) were terminated because of abnormal test results, four stillbirths (1.6%) occurred between weeks 33 and 38, and five pregnancies were lost spontaneously after sampling, corresponding to 2% of unintended fetal losses before 28 weeks of gestation. Of the live-born infants, 2.9% were delivered prematurely, all between weeks 32 and 37. Malformations and orthopedic postural deformities were not associated with leakage after amniocentesis and were found at expected rates. None of the cases was lost to follow-up. The increase in abortion rate caused by early amniocentesis with filter technique is likely to be within the same range as that seen after routine amniocentesis and transabdominal chorionic villus sampling, although the sample is too small for a proper risk evaluation.
报告了连续249例低风险妊娠的胎儿及新生儿结局，这些妊娠在平均孕龄12.5周时采用过滤技术进行了早期羊膜腔穿刺术，以提高细胞培养的成功率。3例妊娠（1.2%）因检测结果异常而终止，4例死产（1.6%）发生在孕33至38周之间，5例妊娠在采样后自然流产，相当于孕28周前意外胎儿丢失的2%。在活产婴儿中，2.9%为早产，均发生在孕32至37周之间。畸形和骨科姿势畸形与羊膜腔穿刺术后渗漏无关，且发生率与预期相符。无一例失访。尽管样本量过小无法进行适当的风险评估，但采用过滤技术的早期羊膜腔穿刺术导致的流产率增加可能与常规羊膜腔穿刺术和经腹绒毛取样后的流产率增加幅度相同。
