Benacerraf B R, Greene M F, Saltzman D H, Barss V A, Penso C A, Nadel A S, Heffner L J, Stryker J M, Sandstrom M M, Frigoletto F D
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Radiology. 1988 Dec;169(3):709-10. doi: 10.1148/radiology.169.3.3055033.
Early amniocentesis at 11-14 weeks gestation was evaluated in 100 consecutive patients to see how this technique compares with later amniocentesis. There were no complications as a consequence of the procedure or related pregnancy losses of chromosomally normal fetuses. Samples obtained from three (3%) patients showed insufficient cell growth; two of these patients elected a repeat procedure, which yielded a normal karyotype in each case. There were five abnormal karyotypes, one of which was a culture artifact; in the latter case, repeat amniocentesis at 15 weeks yielded a normal result. Of the 95 pregnancies with normal karyotypes, 94 were progressing normally at follow-up, and one patient elected pregnancy termination because of maternal indications. It appears that early amniocentesis may be an attractive alternative to traditional amniocentesis, in that it provides results at an earlier gestational age and may avoid certain disadvantages of chorionic villus sampling.
对100例连续妊娠的患者进行了妊娠11 - 14周早期羊膜腔穿刺术评估，以观察该技术与晚期羊膜腔穿刺术相比如何。该操作未导致任何并发症，也没有因染色体正常胎儿的相关妊娠丢失。从3例（3%）患者获取的样本显示细胞生长不足；其中2例患者选择重复操作，每次均得到正常核型。有5例核型异常，其中1例是培养假象；在后一种情况下，15周时重复羊膜腔穿刺术结果正常。在95例核型正常的妊娠中，94例在随访中进展正常，1例患者因母体指征选择终止妊娠。早期羊膜腔穿刺术似乎可能是传统羊膜腔穿刺术的一个有吸引力的替代方法，因为它能在更早的孕周提供结果，并且可能避免绒毛取样的某些缺点。
