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1
A single retroviral gag precursor signal peptide recognized by FBL-3 tumor-specific cytotoxic T lymphocytes.一种被FBL-3肿瘤特异性细胞毒性T淋巴细胞识别的单一逆转录病毒gag前体信号肽。
J Virol. 1995 Nov;69(11):6735-41. doi: 10.1128/JVI.69.11.6735-6741.1995.
2
Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors.从Friend、莫洛尼和劳舍尔鼠白血病病毒诱导的肿瘤中鉴定出FBL-3白血病中由gag编码的细胞毒性T淋巴细胞表位，该表位为上述三种病毒所共有。
J Virol. 1996 Nov;70(11):7773-82. doi: 10.1128/JVI.70.11.7773-7782.1996.
3
Overlapping epitopes of friend murine leukemia virus gag-encoded leader sequence recognized by single cytotoxic T-lymphocyte clones.单个细胞毒性T淋巴细胞克隆识别的Friend小鼠白血病病毒gag编码前导序列的重叠表位。
Immunol Lett. 1998 May;62(1):33-8. doi: 10.1016/s0165-2478(98)00020-0.
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Expression of a tolerizing tumor antigen in peripheral tissue does not preclude recovery of high-affinity CD8+ T cells or CTL immunotherapy of tumors expressing the antigen.外周组织中耐受性肿瘤抗原的表达并不妨碍高亲和力CD8+ T细胞的恢复或对表达该抗原肿瘤的CTL免疫治疗。
J Immunol. 2001 Feb 15;166(4):2863-70. doi: 10.4049/jimmunol.166.4.2863.
5
FBL-reactive CD8+ cytotoxic and CD4+ helper T lymphocytes recognize distinct Friend murine leukemia virus-encoded antigens.FBL反应性CD8 + 细胞毒性T淋巴细胞和CD4 + 辅助性T淋巴细胞识别不同的Friend鼠白血病病毒编码抗原。
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Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells.FBL-3肿瘤细胞上表达的病毒编码辅助性T细胞表位的多样性。
J Virol. 1993 Aug;67(8):4533-42. doi: 10.1128/JVI.67.8.4533-4542.1993.
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Rejection of an IA+ variant line of FBL-3 leukemia by cytotoxic T lymphocytes with CD4+ and CD4-CD8- T cell receptor-alpha beta phenotypes generated in CD8-depleted C57BL/6 mice.在CD8缺失的C57BL/6小鼠中产生的具有CD4⁺以及CD4⁻CD8⁻T细胞受体αβ表型的细胞毒性T淋巴细胞对FBL-3白血病的IA⁺变异株系的排斥反应。
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Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors.受感染供者外周血中人类免疫缺陷病毒特异性细胞毒性T细胞持续高频率存在。
Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5773-7. doi: 10.1073/pnas.92.13.5773.
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Predominant use of a T-cell receptor V beta gene family in simian immunodeficiency virus Gag-specific cytotoxic T lymphocytes in a rhesus monkey.恒河猴中猿猴免疫缺陷病毒Gag特异性细胞毒性T淋巴细胞中T细胞受体Vβ基因家族的主要使用情况
J Virol. 1992 Jun;66(6):3913-7. doi: 10.1128/JVI.66.6.3913-3917.1992.
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Friend virus-specific cytotoxic T lymphocytes recognize both gag and env gene-encoded specificities.Friend病毒特异性细胞毒性T淋巴细胞识别gag和env基因编码的特异性。
J Exp Med. 1986 Jul 1;164(1):211-26. doi: 10.1084/jem.164.1.211.

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Role of natural killer cells in resistance against friend retrovirus-induced leukemia.自然杀伤细胞在抗Friend逆转录病毒诱导的白血病中的作用。
J Virol. 2001 Apr;75(7):3152-63. doi: 10.1128/JVI.75.7.3152-3163.2001.
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Hierarchal utilization of different T-cell receptor Vbeta gene segments in the CD8(+)-T-cell response to an immunodominant Moloney leukemia virus-encoded epitope in vivo.体内CD8(+) T细胞对莫洛尼白血病病毒编码的免疫显性表位应答中不同T细胞受体Vβ基因片段的分层利用
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Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors.针对主要组织相容性复合体II类阴性肿瘤诱导细胞毒性T淋巴细胞的最佳诱导对特定辅助性T细胞的需求。
J Exp Med. 1998 Mar 2;187(5):693-702. doi: 10.1084/jem.187.5.693.
5
Immunity to retroviral infection: the Friend virus model.对逆转录病毒感染的免疫：弗瑞德病毒模型
Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7811-6. doi: 10.1073/pnas.94.15.7811.
6
Characterization of glycosylated Gag expressed by a neurovirulent murine leukemia virus: identification of differences in processing in vitro and in vivo.一种神经毒性小鼠白血病病毒表达的糖基化Gag的特性：体外和体内加工差异的鉴定。
J Virol. 1997 Jul;71(7):5355-60. doi: 10.1128/JVI.71.7.5355-5360.1997.
7
Identification of type-specific cytotoxic T lymphocyte responses to homologous viral proteins in laboratory workers accidentally infected with HIV-1.在意外感染HIV-1的实验室工作人员中鉴定针对同源病毒蛋白的型特异性细胞毒性T淋巴细胞反应。
J Clin Invest. 1997 Feb 15;99(4):752-62. doi: 10.1172/JCI119221.
8
Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors.从Friend、莫洛尼和劳舍尔鼠白血病病毒诱导的肿瘤中鉴定出FBL-3白血病中由gag编码的细胞毒性T淋巴细胞表位，该表位为上述三种病毒所共有。
J Virol. 1996 Nov;70(11):7773-82. doi: 10.1128/JVI.70.11.7773-7782.1996.

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Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia.具有白血病特征的疾病在成年瑞士小鼠中的无细胞传播。
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一种被FBL-3肿瘤特异性细胞毒性T淋巴细胞识别的单一逆转录病毒gag前体信号肽。

A single retroviral gag precursor signal peptide recognized by FBL-3 tumor-specific cytotoxic T lymphocytes.

作者信息

Kondo T, Uenishi H, Shimizu T, Hirama T, Iwashiro M, Kuribayashi K, Tamamura H, Fujii N, Fujisawa R, Miyazawa M

机构信息

Department of Biophysics, Faculty of Science, Kyoto University, Japan.

出版信息

J Virol. 1995 Nov;69(11):6735-41. doi: 10.1128/JVI.69.11.6735-6741.1995.

DOI:10.1128/JVI.69.11.6735-6741.1995
PMID:7474084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189584/
Abstract

Several dominant T-cell receptors of cytotoxic T-lymphocyte (CTL) clones specific for FBL-3 tumor antigen were clonally amplified in mixed lymphocyte tumor cell cultures derived from an individual immune mouse. Every CTL clone analyzed had a common specificity for a single epitope in the precursor to cell membrane-associated nonstructural gag-encoded protein, Pr75gag, which can be minimally identified by nine amino acid residues, SIVLCCLCL. This epitope is located within the hydrophobic signal sequence motif that mediates translocation of the protein into the endoplasmic reticulum. These novel observations suggest that expression of Pr75gag in FBL-3 tumor cells led to the amplification of CTLs which recognize the signal sequence of the nonstructural gag-encoded glycoprotein precursor.

摘要

在源自一只免疫小鼠的混合淋巴细胞肿瘤细胞培养物中，对几种针对FBL - 3肿瘤抗原的细胞毒性T淋巴细胞（CTL）克隆的主要T细胞受体进行了克隆扩增。分析的每个CTL克隆对细胞膜相关非结构gag编码蛋白Pr75gag前体中的单个表位具有共同的特异性，该表位可由九个氨基酸残基SIVLCCLCL最小限度地鉴定。此表位位于介导蛋白质转运至内质网的疏水信号序列基序内。这些新发现表明，FBL - 3肿瘤细胞中Pr75gag的表达导致了识别非结构gag编码糖蛋白前体信号序列的CTL的扩增。