• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Immunogenic determinants of a neuropathogenic murine leukemia virus.一种神经致病性小鼠白血病病毒的免疫原性决定簇。
J Virol. 1995 Nov;69(11):6847-51. doi: 10.1128/JVI.69.11.6847-6851.1995.
2
At least four non-env factors that reside in the LTR, in the 5'-non-coding region, in gag and in part of pol affect neuropathogenicity of PVC-441 murine leukemia virus (MuLV).至少有四个非env因素，分别存在于长末端重复序列（LTR）、5'-非编码区、gag基因以及pol基因的部分区域，这些因素会影响PVC - 441小鼠白血病病毒（MuLV）的神经致病性。
Virus Res. 2000 Aug;69(1):17-30. doi: 10.1016/s0168-1702(00)00166-0.
3
Viral determinants that control the neuropathogenicity of PVC-211 murine leukemia virus in vivo determine brain capillary endothelial cell tropism of the virus in vitro.在体内控制PVC - 211鼠白血病病毒神经致病性的病毒决定因素，在体外决定了该病毒对脑毛细血管内皮细胞的嗜性。
J Virol. 1993 Aug;67(8):4580-7. doi: 10.1128/JVI.67.8.4580-4587.1993.
4
Different abilities of Friend murine leukemia virus (MuLV) and Moloney MuLV to induce promonocytic leukemia are due to determinants in both psi-gag-PR and env regions.弗瑞德氏鼠白血病病毒（MuLV）和莫洛尼氏鼠白血病病毒诱导前单核细胞白血病的能力不同，这是由于ψ- gag - PR和env区域中的决定因素所致。
J Virol. 1994 Aug;68(8):5100-7. doi: 10.1128/JVI.68.8.5100-5107.1994.
5
FBL-reactive CD8+ cytotoxic and CD4+ helper T lymphocytes recognize distinct Friend murine leukemia virus-encoded antigens.FBL反应性CD8 + 细胞毒性T淋巴细胞和CD4 + 辅助性T淋巴细胞识别不同的Friend鼠白血病病毒编码抗原。
J Exp Med. 1989 Feb 1;169(2):457-67. doi: 10.1084/jem.169.2.457.
6
The entire nucleotide sequence of friend-related and paralysis-inducing PVC-441 murine leukemia virus (MuLV) and its comparison with those of PVC-211 MuLV and Friend MuLV.与弗瑞德相关的致麻痹性PVC - 441小鼠白血病病毒（MuLV）的完整核苷酸序列及其与PVC - 211 MuLV和弗瑞德MuLV的比较。
J Virol. 1998 Apr;72(4):3423-6. doi: 10.1128/JVI.72.4.3423-3426.1998.
7
Virus-specific cytotoxic lymphocyte response in a neurotropic murine leukemia virus infection.嗜神经性小鼠白血病病毒感染中的病毒特异性细胞毒性淋巴细胞反应。
J Neuroimmunol. 1991 Jan;31(1):9-17. doi: 10.1016/0165-5728(91)90081-h.
8
Molecular characterization of a neuropathogenic and nonerythroleukemogenic variant of Friend murine leukemia virus PVC-211.弗氏小鼠白血病病毒PVC-211神经致病且非红白血病致病变体的分子特征分析
J Virol. 1992 May;66(5):2798-806. doi: 10.1128/JVI.66.5.2798-2806.1992.
9
Impaired generation of anti-AKR/Gross murine leukemia virus cytotoxic T lymphocytes in mice experimentally infected with MuLV.在实验感染鼠白血病病毒（MuLV）的小鼠中，抗AKR/Gross鼠白血病病毒细胞毒性T淋巴细胞的生成受损。
Viral Immunol. 1996;9(2):107-19. doi: 10.1089/vim.1996.9.107.
10
Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors.从Friend、莫洛尼和劳舍尔鼠白血病病毒诱导的肿瘤中鉴定出FBL-3白血病中由gag编码的细胞毒性T淋巴细胞表位，该表位为上述三种病毒所共有。
J Virol. 1996 Nov;70(11):7773-82. doi: 10.1128/JVI.70.11.7773-7782.1996.

引用本文的文献

1
T cell immunity in neonates.新生儿的T细胞免疫
Immunol Res. 2000;22(2-3):177-90. doi: 10.1385/IR:22:2-3:177.
2
Amphotropic murine leukemia viruses induce spongiform encephalomyelopathy.双嗜性鼠白血病病毒可诱发海绵状脑脊髓病。
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5837-42. doi: 10.1073/pnas.94.11.5837.

本文引用的文献

1
Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection.1型原发性人类免疫缺陷病毒感染中，病毒特异性CD8 + 细胞毒性T淋巴细胞活性与病毒血症控制相关。
J Virol. 1994 Sep;68(9):6103-10. doi: 10.1128/JVI.68.9.6103-6110.1994.
2
Molecular cloning of infectious viral DNA from ecotropic neurotropic wild mouse retrovirus.从亲嗜性嗜神经性野生小鼠逆转录病毒中克隆感染性病毒DNA
J Virol. 1983 Mar;45(3):1159-63. doi: 10.1128/JVI.45.3.1159-1163.1983.
3
Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase.莫洛尼鼠白血病病毒突变体的分离与特性：一种用于检测病毒体逆转录酶释放的快速检测方法的应用
J Virol. 1981 Apr;38(1):239-48. doi: 10.1128/JVI.38.1.239-248.1981.
4
Role of immunity in age-related resistance to paralysis after murine leukemia virus infection.免疫在小鼠白血病病毒感染后与年龄相关的麻痹抗性中的作用。
J Virol. 1984 Dec;52(3):734-8. doi: 10.1128/JVI.52.3.734-738.1984.
5
Physical mapping of the paralysis-inducing determinant of a wild mouse ecotropic neurotropic retrovirus.一种野生小鼠亲嗜性嗜神经性逆转录病毒致瘫决定簇的物理图谱分析
J Virol. 1984 Nov;52(2):356-63. doi: 10.1128/JVI.52.2.356-363.1984.
6
A new technique for the assay of infectivity of human adenovirus 5 DNA.一种检测人腺病毒5型DNA感染性的新技术。
Virology. 1973 Apr;52(2):456-67. doi: 10.1016/0042-6822(73)90341-3.
7
Plaque assay techniques for murine leukemia viruses.小鼠白血病病毒的噬斑测定技术
Virology. 1970 Dec;42(4):1136-9. doi: 10.1016/0042-6822(70)90362-4.
8
Identification of point mutations in the envelope gene of Moloney murine leukemia virus TB temperature-sensitive paralytogenic mutant ts1: molecular determinants for neurovirulence.莫洛尼鼠白血病病毒TB温度敏感致瘫突变体ts1包膜基因点突变的鉴定：神经毒力的分子决定因素
J Virol. 1988 Jan;62(1):357-60. doi: 10.1128/JVI.62.1.357-360.1988.
9
Activation of cellular oncogenes in human and mouse leukemia-lymphomas: spontaneous and induced oncogene expression in murine B lymphocytic neoplasms.人类和小鼠白血病-淋巴瘤中细胞癌基因的激活：小鼠B淋巴细胞肿瘤中的自发和诱导癌基因表达
Cancer Invest. 1987;5(4):345-68.
10
Retrovirus antigens recognized by cytolytic T lymphocytes activate tumor rejection in vivo.被细胞溶解性T淋巴细胞识别的逆转录病毒抗原在体内激活肿瘤排斥反应。
Cell. 1987 Jan 30;48(2):231-40. doi: 10.1016/0092-8674(87)90426-0.

一种神经致病性小鼠白血病病毒的免疫原性决定簇。

Immunogenic determinants of a neuropathogenic murine leukemia virus.

作者信息

Robbins D S, Remington M P, Sarzotti M, St Louis D, Hoffman P M

机构信息

Research Service, Department of Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA.

出版信息

J Virol. 1995 Nov;69(11):6847-51. doi: 10.1128/JVI.69.11.6847-6851.1995.

DOI:10.1128/JVI.69.11.6847-6851.1995
PMID:7474098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189598/
Abstract

Previous studies of Cas-Br-M murine leukemia virus (MuLV) (Cas-MuLV) infection demonstrated that cytotoxic T cells (CTL) of the CD8+ phenotype play a role in resistance to the neuropathogenic effects of the virus in NFS/N mice. In the current study, we sought to identify the Cas-MuLV epitopes that are immunogenic for the CTL response. Infection of adult NFS/N mice with a well-characterized neuropathogenic variant of Friend MuLV, PVC-211 MuLV (PVC-MuLV), was not immunogenic for MuLV-specific CTL. Therefore, we constructed chimeric viruses between Cas-MuLV and PVC-MuLV. Infectious chimeras contained the Cas-MuLV env gene on a PVC-MuLV background (PVC-CasenvMuLV) and the PVC-MuLV env gene on a Cas-MuLV background (Cas-PVCenvMuLV). Cas-MuLV-specific CTL were found following inoculation of both the chimeric viruses and the parental Cas-MuLV but not the parental PVC-MuLV, despite evidence of antibody responses to both parental and chimeric MuLV. CTL generated in response to infection with PVC-CasenvMuLV and Cas-PVCenvMuLV were exclusively of the CD8+ phenotype. These results indicate that both the env and gag-pol regions of Cas-MuLV express epitopes that are immunogenic for CTL.

摘要

先前对卡斯-布伦-墨菲氏鼠白血病病毒（Cas-Br-M MuLV，简称Cas-MuLV）感染的研究表明，CD8+表型的细胞毒性T细胞（CTL）在NFS/N小鼠抵抗该病毒神经致病作用中发挥作用。在本研究中，我们试图鉴定对CTL反应具有免疫原性的Cas-MuLV表位。用特征明确的弗氏鼠白血病病毒神经致病变种PVC-211 MuLV（PVC-MuLV）感染成年NFS/N小鼠，对MuLV特异性CTL不具有免疫原性。因此，我们构建了Cas-MuLV和PVC-MuLV之间的嵌合病毒。有感染性的嵌合体包括在PVC-MuLV背景上携带Cas-MuLV env基因的病毒（PVC-CasenvMuLV）以及在Cas-MuLV背景上携带PVC-MuLV env基因的病毒（Cas-PVCenvMuLV）。尽管有证据表明对亲本和嵌合MuLV均有抗体反应，但接种嵌合病毒和亲本Cas-MuLV后均发现了Cas-MuLV特异性CTL，而接种亲本PVC-MuLV后未发现。由PVC-CasenvMuLV和Cas-PVCenvMuLV感染产生的CTL均为CD8+表型。这些结果表明，Cas-MuLV的env和gag-pol区域均表达对CTL具有免疫原性的表位。