柯萨奇病毒B4的VP4编码序列中的一个点突变影响毒力。
A point mutation in the VP4 coding sequence of coxsackievirus B4 influences virulence.
作者信息
Ramsingh A I, Collins D N
机构信息
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-2002, USA.
出版信息
J Virol. 1995 Nov;69(11):7278-81. doi: 10.1128/JVI.69.11.7278-7281.1995.
Abstract
In analyzing the molecular determinants of virulence of coxsackievirus B4, chimeric viruses were constructed from avirulent and virulent viruses. The vCB424 recombinant contained a single nucleotide substitution on an avirulent genetic background, resulting in replacement of Ser-16 of VP4 with Arg-16. Mice infected with vCB424 displayed an intermediate phenotype.
摘要
在分析柯萨奇病毒B4毒力的分子决定因素时，从无毒和有毒病毒构建了嵌合病毒。vCB424重组病毒在无毒遗传背景上有一个单核苷酸替换，导致VP4的第16位丝氨酸被第16位精氨酸取代。感染vCB424的小鼠表现出中间表型。
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