有证据表明，毒力定位于柯萨奇病毒B4基因组的P1区域。
Evidence suggesting that virulence maps to the P1 region of the coxsackievirus B4 genome.
作者信息
Ramsingh A, Hixson A, Duceman B, Slack J
机构信息
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.
出版信息
J Virol. 1990 Jun;64(6):3078-81. doi: 10.1128/JVI.64.6.3078-3081.1990.
Abstract
A chimeric virus containing the P1 region of a virulent variant of coxsackievirus B4 and the P2 and P3 regions of a nonvirulent strain was constructed from cDNA clones. The chimeric virus induced pancreatitis with concurrent hypoglycemia similar to that observed in mice infected with the virulent variant.
摘要
一种嵌合病毒由互补脱氧核糖核酸（cDNA）克隆构建而成，其包含柯萨奇病毒B4强毒株的P1区域以及无毒株的P2和P3区域。该嵌合病毒诱发的胰腺炎伴有低血糖症，这与感染强毒株的小鼠中观察到的情况相似。
Zotero 插件