Cook W J, Lin S M, DeLuca N A, Coen D M
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
J Virol. 1995 Nov;69(11):7291-4. doi: 10.1128/JVI.69.11.7291-7294.1995.
Regulated expression of thymidine kinase mRNA in herpes simplex virus mutants harboring thymidine kinase promoters that lacked functional TATA boxes was largely unaffected by additional sequence alterations around the transcriptional start site. A strong initiator element increased the regulated expression of a TATA-containing promoter by 50% but did not affect that of the TATA-less promoter. Thus, initiator elements exert only small effects in this promoter context.
在含有缺乏功能性TATA框的胸苷激酶启动子的单纯疱疹病毒突变体中，胸苷激酶mRNA的调控表达在很大程度上不受转录起始位点周围其他序列改变的影响。一个强起始子元件使含TATA启动子的调控表达增加了50%，但对无TATA启动子的调控表达没有影响。因此，在这种启动子环境中，起始子元件的作用很小。
