单纯疱疹病毒1型Vmw110环指螺旋中的点突变影响基因表达的激活、病毒生长以及与含早幼粒细胞白血病蛋白的核结构的相互作用。
Point mutations in the herpes simplex virus type 1 Vmw110 RING finger helix affect activation of gene expression, viral growth, and interaction with PML-containing nuclear structures.
作者信息
Everett R, O'Hare P, O'Rourke D, Barlow P, Orr A
机构信息
Medical Research Council Virology Unit, Glasgow, Scotland.
出版信息
J Virol. 1995 Nov;69(11):7339-44. doi: 10.1128/JVI.69.11.7339-7344.1995.
Abstract
Herpes simplex virus type 1 immediate-early protein Vmw110 (also known as ICP0) has been implicated in the control of the balance between the lytic and latent states, but the precise mechanisms by which it exerts its effects are unknown. Vmw110 includes a characteristic zinc binding domain, termed the C3HC4 domain or RING finger, which is essential for its function. The solution structure of a related herpesvirus RING finger domain suggested that an amphipathic alpha helix might be an important functional component of the RING finger. In this paper, we show that the equivalent region of Vmw110 is important for virus growth in tissue culture and for the normal interaction of Vmw110 with nuclear structures which include the PML protein.
摘要
单纯疱疹病毒I型立即早期蛋白Vmw110（也称为ICP0）与裂解状态和潜伏状态之间平衡的控制有关，但其发挥作用的确切机制尚不清楚。Vmw110包含一个特征性的锌结合结构域，称为C3HC4结构域或环指结构域，这对其功能至关重要。一种相关疱疹病毒环指结构域的溶液结构表明，两亲性α螺旋可能是环指结构域的重要功能成分。在本文中，我们表明Vmw110的等效区域对于病毒在组织培养中的生长以及Vmw110与包括PML蛋白在内的核结构的正常相互作用很重要。
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The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency.单纯疱疹病毒1型调节蛋白ICP0在急性感染和潜伏激活过程中增强病毒复制。
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The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion.t(15;17)易位以视黄酸可逆的方式改变一个核体。
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