Jubier-Maurin V, Sarni-Manchado P, Veas F, Vidal N, Bibollet-Ruche F, Durand J P, Galat-Luong A, Cuny G
Laboratoire Rétrovirus, Institute Français de Recherche Scientifique pour le Développment en Coopération (ORSTOM), Montpellier, France.
J Virol. 1995 Nov;69(11):7349-53. doi: 10.1128/JVI.69.11.7349-7353.1995.
The high seroprevalence of simian immunodeficiency viruses (SIVs) in African green monkeys (AGMs) without immunological defects in their natural hosts has prompted consideration of SIV-infected AGMs as a model of apathogenic SIV infection. Study of the molecular mechanisms of SIVagm asymptomatic infection could thus provide clues for understanding the pathogenesis of human immunodeficiency viruses. Regulatory genes could be candidates for genetic control of SIVagm apathogenicity. We have characterized Vpr, Tat, Rev, and Nef genes of two SIVagm strains isolated from naturally infected sabaeus monkeys captured in Senegal. The results provide further evidence that SIVagm from West African green monkeys is the most divergent class of AGM viruses, with structural features in long terminal repeat sequences and Vpr and Tat genes that distinguish them from viruses isolated from other AGM species (vervet, grivet, and tantalus monkeys).
在自然宿主中无免疫缺陷的非洲绿猴（AGM）体内，猿猴免疫缺陷病毒（SIV）的血清阳性率很高，这促使人们将感染SIV的AGM视为无致病性SIV感染的模型。因此，对SIVagm无症状感染分子机制的研究可为理解人类免疫缺陷病毒的发病机制提供线索。调控基因可能是SIVagm无致病性遗传控制的候选基因。我们已经对从在塞内加尔捕获的自然感染的黑绿猴中分离出的两种SIVagm毒株的Vpr、Tat、Rev和Nef基因进行了表征。结果提供了进一步的证据，表明来自西非绿猴的SIVagm是AGM病毒中差异最大的一类，其长末端重复序列以及Vpr和Tat基因的结构特征使其与从其他AGM物种（绿猴、长尾猴和白臀长尾猴）分离出的病毒有所区别。
