Khan D M, Bhutta Z A
Department of Paediatrics, Aga Khan University, Karachi.
J Pak Med Assoc. 1995 Jun;45(6):147-50.
Ciprofloxacin is a new orally administrable fluoroquinolones, with considerable efficacy against multiresistant organisms. Its use in the paediatric age group however, is controversial because of the risk of potential articular toxicity. We retrospectively reviewed ciprofloxacin usage over a 32 week periods (June, 1991-September, 1993) in paediatric inpatients at The Aga Khan University Hospital. Ciprofloxacin was used in 21 cases, singly in 11 (52%) and in combination with other antibiotics in a further 10 (48%). The response to therapy was adjudged as 'good' or 'fair' in 13 (62%) cases. Ciprofloxacin was the only sensitive antibiotic in 4 (19%) and resistance to it was detected in another 4 (19%) cases. Despite all efforts, adequate follow-up could only be achieved in a third of the patients. Although no toxic or side effects were detected, in view of poor follow-up and emergence of ciprofloxacin resistant strains, our experience highlights the need to regulate ciprofloxacin use in the paediatric age group.
环丙沙星是一种新型的可口服的氟喹诺酮类药物，对多重耐药菌有显著疗效。然而，由于存在潜在的关节毒性风险，其在儿童年龄组中的使用存在争议。我们回顾性地分析了阿迦汗大学医院儿科住院患者在32周期间（1991年6月至1993年9月）环丙沙星的使用情况。21例患者使用了环丙沙星，其中11例（52%）单独使用，另外10例（48%）与其他抗生素联合使用。13例（62%）患者的治疗反应被判定为“良好”或“尚可”。4例（19%）患者中环丙沙星是唯一敏感的抗生素，另外4例（19%）患者检测到对环丙沙星耐药。尽管尽了一切努力，只有三分之一的患者得到了充分的随访。虽然未检测到毒性或副作用，但鉴于随访不佳以及环丙沙星耐药菌株的出现，我们的经验凸显了在儿童年龄组中规范使用环丙沙星的必要性。
