Postnikov S S, Semykin S Iu, Kapranov N I, Perederko L V, Polikarpova S V
Russian Medical University, Moscow.
Antibiot Khimioter. 2000;45(4):14-7.
Ciprofloxacin clinical and bacteriological efficacies, as well as tolerability mainly with respect to chondrotoxicity were evaluated in the treatment of children with mucoviscidosis. The drug was shown to have high clinical and moderate bacteriological efficacies. As for its tolerability, adverse reactions chiefly associated with affection of the gastrointestinal tract, i.e. nausea, stomach pain, diarrhea, increased transaminase levels were recorded. The arthrotoxicity episode was single and transitory. The use of ciprofloxacin had no negative effect on the children growth. No chondrotoxic effect of ciprofloxacin in the treatment of children was observed which is explained in the paper. It is concluded that ciprofloxacin is in general an efficient and safe antibiotic useful for the treatment of children.
在治疗患有黏液黏稠病的儿童时，评估了环丙沙星的临床和细菌学疗效以及主要关于软骨毒性的耐受性。结果显示该药物具有较高的临床疗效和中等的细菌学疗效。至于其耐受性，记录到主要与胃肠道不适相关的不良反应，即恶心、胃痛、腹泻、转氨酶水平升高。关节毒性事件是单一且短暂的。使用环丙沙星对儿童生长没有负面影响。在儿童治疗中未观察到环丙沙星的软骨毒性作用，本文对此进行了解释。结论是，环丙沙星总体上是一种有效且安全的抗生素，可用于治疗儿童。
