Zaslavskaia R M, Akhmetov K Zh, Teĭblium M M
Klin Med (Mosk). 1995;73(4):57-60.
24-h trends in central and peripheral circulation in response to pharmacological tests were registered in 40 patients with stage II essential hypertension (EH). Rhythmic patterns of hemodynamic parameters (heart rate, systolic pressure, stroke volume, etc.) sensitivity to adelphane-esidrex were found. Hypotensive effect of this drug was maximal in morning hours because of the fall in arterial pressure due to reduced peripheral resistance. Sinepres chronotherapy given to 18 EH patients turned out superior to conventional treatment (1 pill 3 times a day) given to 20 EH patients. When taken into consideration, chronosensitivity to the above drugs may bring about a reduction in daily and course doses and earlier occurrence of a hypotensive effect.
对40例II期原发性高血压（EH）患者进行了药理试验，记录了其中心和外周循环的24小时变化趋势。发现了血流动力学参数（心率、收缩压、每搏输出量等）对阿屈非尼-依西多昔的节律模式敏感性。由于外周阻力降低导致动脉压下降，该药物的降压作用在早晨最为明显。对18例EH患者进行的辛内普时辰疗法被证明优于对20例EH患者进行的传统治疗（每日3次，每次1片）。考虑到对上述药物的时辰敏感性，可能会减少每日和疗程剂量，并更早出现降压效果。
