Holden A V, Zhang H
Department of Physiology, University of Leeds, U.K.
J Theor Biol. 1995 Aug 21;175(4):545-51. doi: 10.1006/jtbi.1995.0162.
A two-dimensional excitable medium model of atrial tissue has been constructed by incorporating the Earm-Hilgemann-Noble excitation equations for membrane voltage-dependent ionic currents and pump exchanger currents, time-dependent changes in intracellular and extracellular ionic concentrations, and storage and release of Ca2+, for an atrial cell in an homogeneous partial differential equation. A diffusion coefficient of 1.25 cm2 sec-1 gives the conduction velocity of a solitary planar wave as 0.6 m sec-1. A spiral wave with a period of 78 msec develops from a broken wavefront, and initially rotates around a circular core of 2 mm diameter. After 1.5 sec of rotation, a biperiodic meander, with 6 epicycles/cycle, develops. This simple meander pattern is reflected in a period-6 modulation of the intervals between successive wavefronts.
通过将用于膜电压依赖性离子电流和泵交换电流的Earm-Hilgemann-Noble激发方程、细胞内和细胞外离子浓度的时间依赖性变化以及Ca2+的储存和释放纳入一个均匀偏微分方程中的心房细胞，构建了心房组织的二维可兴奋介质模型。扩散系数为1.25平方厘米/秒时，孤立平面波的传导速度为0.6米/秒。一个周期为78毫秒的螺旋波从破碎的波前发展而来，最初围绕直径为2毫米的圆形核心旋转。旋转1.5秒后，出现了每周期有6个本轮的双周期蜿蜒。这种简单的蜿蜒模式反映在连续波前之间间隔的周期为6的调制中。
