Sánchez de Rojas V R, Ortega T, Villar A
Departamento de Farmacologia, Facultad de Farmacia, Universidad Complutense de Madrid, Spain.
J Ethnopharmacol. 1995 Apr;46(1):59-62. doi: 10.1016/0378-8741(95)01229-7.
The medicinal plant Cistus populifolius L., shows an important dose-dependent spasmolytic activity. The ability of the Cistus extract to inhibit both acetylcholine (ACh) (3.4 x 10(-8)-6.8 x 10(-5) M) and CaCl2 (2 x 10(-4)-1.28 x 10(-2) M)-induced contractions and the relaxing effect on K+ (75 mM)-induced contractions may indicate a non-specific receptor antagonist. However, this action may be related to the influx of extracellular Ca2+. These antispasmodic effects are partly consistent with the use of C. populifolius in folk medicine for certain gastrointestinal disorders.
药用植物波叶岩蔷薇（Cistus populifolius L.）表现出重要的剂量依赖性解痉活性。波叶岩蔷薇提取物抑制乙酰胆碱（ACh）（3.4×10⁻⁸ - 6.8×10⁻⁵ M）和氯化钙（CaCl₂）（2×10⁻⁴ - 1.28×10⁻² M）诱导的收缩的能力以及对钾离子（K⁺）（75 mM）诱导的收缩的松弛作用可能表明其为非特异性受体拮抗剂。然而，这种作用可能与细胞外钙离子的内流有关。这些解痉作用部分与波叶岩蔷薇在民间医学中用于某些胃肠道疾病的用途相符。
