McCulloch P, Choy A, Martin L
University Department of Surgery, Royal Liverpool University Hospital, UK.
Lancet. 1995 Nov 18;346(8986):1334-5. doi: 10.1016/s0140-6736(95)92345-4.
Tumour angiogenesis is a powerful prognostic indicator in breast cancer. Shedding of tumour cells into the bloodstream is essential for haematogenous metastasis. The relation between cell shedding and angiogenesis in human cancer is not known. We studied vascular density and cell shedding in 16 women undergoing breast cancer surgery. Circulating cells were found in one patient before, in six during, and none after operation. Vascular density was related to detection of circulating tumour cells during surgery (correlation coefficient for first intraoperative sampling = 0.56, p = 0.024, 95% CI 0.08 to 0.83). Tumour cell shedding during surgery is related to vascular density; the relevance of this relation to the prognostic significance of vascular density in breast cancer merits further study.
肿瘤血管生成是乳腺癌中一个强有力的预后指标。肿瘤细胞进入血液循环是血行转移的必要条件。人类癌症中细胞脱落与血管生成之间的关系尚不清楚。我们研究了16例接受乳腺癌手术的女性的血管密度和细胞脱落情况。术前在1例患者中发现循环细胞，术中在6例患者中发现，术后未发现。血管密度与手术期间循环肿瘤细胞的检测相关（首次术中采样的相关系数=0.56，p=0.024，95%CI 0.08至0.83）。手术期间肿瘤细胞脱落与血管密度相关；这种关系与乳腺癌中血管密度的预后意义的相关性值得进一步研究。
