睾酮对大鼠肝脏嘌呤核苷酸代谢的影响。

The influence of testosterone on purine nucleotide metabolism in rat liver.

作者信息

Pizzichini M, Leoncini R, Vannoni D, Marinello E, Pagani R

机构信息

Istituto di Biochimica e di Enzimologia, University of Siena, Italy.

出版信息

Life Sci. 1995;57(23):2127-35. doi: 10.1016/0024-3205(95)02205-w.

DOI:10.1016/0024-3205(95)02205-w

PMID:7475965

Abstract

Purine nucleotide metabolism was studied in rat liver by following the incorporation of 14C-formate into soluble nucleotides, uric acid and RNA ribonucleotides. After castration, GMP formation was less than that of AMP, and purine nucleotide catabolism and RNA synthesis decreased. Testosterone administration did not modify GMP or AMP synthesis, but restored purine nucleotide catabolism and RNA production to normal values. These results demonstrate the influence of testosterone on purine nucleotide metabolism in a non-reproductive organ.

摘要

通过追踪14C-甲酸掺入可溶性核苷酸、尿酸和RNA核糖核苷酸的情况，对大鼠肝脏中的嘌呤核苷酸代谢进行了研究。去势后，GMP的生成少于AMP，嘌呤核苷酸分解代谢和RNA合成减少。给予睾酮并未改变GMP或AMP的合成，但使嘌呤核苷酸分解代谢和RNA生成恢复到正常水平。这些结果证明了睾酮对非生殖器官中嘌呤核苷酸代谢的影响。