Hu X, Le T H, Parrish T, Erhard P
Department of Radiology, University of Minnesota Medical School, Minneapolis, USA.
Magn Reson Med. 1995 Aug;34(2):201-12. doi: 10.1002/mrm.1910340211.
Image-to-image fluctuation due to physiological motion is a major limitation to the accurate detection of neuronal activity with functional MRI. In this paper, a new and general technique for the estimation and compensation of the physiological effects is presented. By simultaneously monitoring the respiration and heart beat during the acquisition of imaging data, and retrospectively synchronizing the imaging data with physiological activity, physiological effects are estimated and removed. This technique does not rely on the periodicity of the respiration or the heart beat, does not affect the signal changes arising from neuronal activation, and is beneficial to images acquired with any speed. Experimental studies performed with FLASH and EPI sequences have demonstrated that the new technique is effective in reducing physiological fluctuation and improving the sensitivity of functional MRI and is generally applicable.
由于生理运动导致的图像间波动是功能磁共振成像准确检测神经元活动的主要限制。本文提出了一种用于估计和补偿生理效应的新通用技术。通过在采集成像数据期间同时监测呼吸和心跳，并将成像数据与生理活动进行回顾性同步，可估计并消除生理效应。该技术不依赖于呼吸或心跳的周期性，不影响神经元激活引起的信号变化，并且对以任何速度采集的图像都有益。使用FLASH和EPI序列进行的实验研究表明，该新技术在减少生理波动和提高功能磁共振成像的灵敏度方面是有效的，并且普遍适用。
