Taniguchi A, Nakai Y, Doi K, Fukuzawa H, Fukushima M, Kawamura H, Tokuyama K, Suzuki M, Fujitani J, Tanaka H
First Department of Internal Medicine, Kansai-Denryoku Hospital, Osaka, Japan.
Metabolism. 1995 Nov;44(11):1397-400. doi: 10.1016/0026-0495(95)90136-1.
The aim of the present study was to estimate insulin sensitivity (SI), insulin secretion, and glucose effectiveness in 14 obese subjects who were further divided into two groups: one with normal glucose tolerance and the other with impaired glucose tolerance (IGT). Glucose tolerance was determined by criteria of the World Health Organization. All subjects were Japanese. They underwent a modified frequently sampled intravenous glucose tolerance test: glucose (300 mg/kg body weight) was administered, and insulin (20 mU/kg body weight given over 5 minutes) was infused from 20 to 25 minutes after administration of glucose. SI and glucose effectiveness at basal insulin (SG) were estimated by Bergman's minimal model method. Body mass index (33.0 +/- 1.8 v 30.9 +/- 1.5 kg/m2, P > .05) and fasting insulin level (127.9 +/- 30.0 v 107.4 +/- 14.4 pmol/L, P > .05) were higher in obese IGT subjects than in normal obese subjects, but were not statistically significant. With regard to fasting glucose level, obese subjects with IGT (5.9 +/- 0.3 mmol/L) had significantly higher levels than those with normal glucose tolerance (5.1 +/- 0.2 mmol/L, P < .01). There was no significant difference in SI between the two groups (0.53 +/- 0.10 v 0.56 +/- 0.13 x 10(-4).min-1.pmol/L-1, P > .05). Pancreatic insulin secretion expressed as the integrated area of plasma insulin above the basal level during the first 19 minutes was significantly lower in obese subjects with IGT (3,366 +/- 1,495 pmol/L.min) than in those with normal glucose tolerance (16,400 +/- 4,509 pmol/L.min, P < .05).(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的目的是评估14名肥胖受试者的胰岛素敏感性（SI）、胰岛素分泌和葡萄糖有效性，这些受试者被进一步分为两组：一组糖耐量正常，另一组糖耐量受损（IGT）。糖耐量根据世界卫生组织的标准确定。所有受试者均为日本人。他们接受了改良的频繁采样静脉葡萄糖耐量试验：给予葡萄糖（300mg/kg体重），并在给予葡萄糖后20至25分钟内输注胰岛素（20mU/kg体重，5分钟内给予）。基础胰岛素水平下的SI和葡萄糖有效性（SG）通过伯格曼最小模型法进行评估。肥胖IGT受试者的体重指数（33.0±1.8对30.9±1.5kg/m2，P>.05）和空腹胰岛素水平（127.9±30.0对107.4±14.4pmol/L，P>.05）高于正常肥胖受试者，但无统计学意义。关于空腹血糖水平，IGT肥胖受试者（5.9±0.3mmol/L）显著高于糖耐量正常的受试者（5.1±0.2mmol/L，P<.01）。两组之间的SI无显著差异（0.53±0.10对0.56±0.13×10-4.min-1.pmol/L-1，P>.05）。以最初19分钟内血浆胰岛素高于基础水平的积分面积表示的胰腺胰岛素分泌，IGT肥胖受试者（3366±1495pmol/L.min）显著低于糖耐量正常的受试者（16400±4509pmol/L.min，P<.05）。（摘要截断于250字）
