Taniguchi A, Nakai Y, Fukushima M, Imura H, Kawamura H, Nagata I, Florant G L, Tokuyama K
First Department of Internal Medicine, Kansai-Denryoku Hospital, Osaka, Japan.
Metabolism. 1994 Jun;43(6):714-8. doi: 10.1016/0026-0495(94)90119-8.
The aim of the present study was to estimate insulin secretion, insulin sensitivity (SI), and glucose effectiveness (SG) in non-obese Japanese subjects with impaired glucose tolerance (IGT). Ten IGT subjects (five men, five women) and 15 normal-tolerance subjects (seven men, eight women) without a family history of diabetes were studied. They underwent a modified frequently sampled intravenous glucose tolerance test (FSIGT); glucose (300 mg/kg body weight) was administered, and insulin (20 mU/kg over 5 minutes) was infused from 20 to 25 minutes after the administration of glucose. SI and SG were estimated by Bergman's minimal model method. No significant difference was observed in body mass index ([BMI] 22.1 +/- 0.8 v 21.1 +/- 0.5 kg/m2), fasting plasma glucose (5.19 +/- 0.18 v 5.07 +/- 0.11 mmol/L), and insulin levels (50.7 +/- 7.3 v 45.2 +/- 4.5 pmol/L) of subjects with IGT and normal controls. The glucose disappearance rate (KG) was significantly lower in subjects with IGT than in normal-tolerance subjects (1.57 +/- 0.20 v 2.09 +/- 0.15%/min, P < .05). Pancreatic insulin secretion expressed as the integrated area of plasma insulin above the basal level during the first 20 minutes was lower in IGT subjects (2,556 +/- 572 pmol/L x min) than in normal-tolerance subjects (4,957 +/- 800 pmol/L x min, P < .05). SI was not statistically different between the two groups (0.84 +/- 0.13 x 10(-4) v 1.14 +/- 0.15 x 10(-4).min-1.pmol/L-1). However, SG was significantly lower in subjects with IGT than in normal controls (0.013 +/- 0.002 v 0.023 +/- 0.002 min-1, P < .01).(ABSTRACT TRUNCATED AT 250 WORDS)
本研究旨在评估糖耐量受损（IGT）的非肥胖日本受试者的胰岛素分泌、胰岛素敏感性（SI）和葡萄糖效能（SG）。研究了10名IGT受试者（5名男性，5名女性）和15名无糖尿病家族史的糖耐量正常受试者（7名男性，8名女性）。他们接受了改良的频繁采样静脉葡萄糖耐量试验（FSIGT）；给予葡萄糖（300mg/kg体重），并在给予葡萄糖后20至25分钟内输注胰岛素（5分钟内20mU/kg）。SI和SG通过伯格曼最小模型法评估。IGT受试者和正常对照组在体重指数（[BMI]22.1±0.8对21.1±0.5kg/m2）、空腹血糖（5.19±0.18对5.07±0.11mmol/L）和胰岛素水平（50.7±7.3对45.2±4.5pmol/L）方面未观察到显著差异。IGT受试者的葡萄糖消失率（KG）显著低于糖耐量正常受试者（1.57±0.20对2.09±0.15%/分钟，P<.05）。以最初20分钟内血浆胰岛素高于基础水平的积分面积表示的胰腺胰岛素分泌，IGT受试者（2556±572pmol/L·分钟）低于糖耐量正常受试者（4957±800pmol/L·分钟，P<.05）。两组之间的SI无统计学差异（0.84±0.13×10(-4)对1.14±0.15×10(-4)·分钟-1·pmol/L-1）。然而，IGT受试者的SG显著低于正常对照组（0.013±0.002对0.023±0.002分钟-1，P<.01）。（摘要截断于250字）
