Milstein C, de Zegher I, Venot A, Séné B, Pietri P, Dahlberg B
Département de Biostatistiques et Informatique Médicale, et IRT-Eclimed, UFR Cochin-Port Royal, Université René Descartes Paris V, Paris, France.
Methods Inf Med. 1995 Sep;34(4):318-27.
There exists little theoretical analysis how to represent knowledge on drugs required for computerized drug-prescription applications. A work package drug information modeling is described which was part of the European OPADE project. We describe the content and structure of a Drug Knowledge Base (DKB) designed to meet the requirements of decision-support systems in the domain of drug therapy, and to facilitate data transfer from various information sources. The definition of the DKB content is derived from the analysis of information requirements at the various stages of the process of the clinical usage of drugs (prescribing, administration, and follow-up). The DKB structure results from the classification of the various data items along two dimensions: (1) entities in the pharmaco-therapeutic domain for which information must be defined (the PharmacoTherapeutic Group, the Component, the ManufacturedPreparation, and the Presentation), and (2) the validity score of the pharmaco-therapeutic information (international, national, or local).
对于如何在计算机化药物处方应用中表示所需的药物知识，几乎没有理论分析。本文描述了作为欧洲OPADE项目一部分的一个工作包——药物信息建模。我们描述了一个药物知识库（DKB）的内容和结构，该知识库旨在满足药物治疗领域决策支持系统的要求，并促进来自各种信息源的数据传输。DKB内容的定义源自对药物临床使用过程（开处方、给药和随访）各个阶段信息需求的分析。DKB结构源于沿两个维度对各种数据项的分类：（1）必须定义信息的药物治疗领域中的实体（药物治疗组、成分、制剂和剂型），以及（2）药物治疗信息的有效性评分（国际、国家或地方）。
