色氨酸对大鼠和豚鼠葡萄糖合成的不同影响。
Differential effects of tryptophan on glucose synthesis in rats and guinea pigs.
作者信息
Smith S A, Elliott K R, Pogson C I
出版信息
Biochem J. 1978 Dec 15;176(3):817-25. doi: 10.1042/bj1760817.
Abstract
- Tryptophan inhibition of gluconeogenesis in isolated rat liver cells is characterized by a 20 min lag period before linear rates of glucose output are attained. 2. Half-maximal inhibition of gluconeogenesis in isolated rat hepatocytes is produced by approx. 0.1 mM-tryptophan. 3. Tryptophan inhibits gluconeogenesis from all substrates giving rise to oxaloacetate, but stimulates glycerol-fuelled glucose production. 4. Gluconeogenesis in guinea-pig hepatocytes is insensitive to tryptophan. 5. Changes in metabolite concentrations in rat liver cells are consistent with a locus of inhibition at the step catalysed by phosphoenolpyruvate carboxykinase. 6. Inhibition of gluconeogenesis persists in cells from rats pretreated with tryptophan in vivo. 7. Tryptophan has no effect on urea production from alanine, but decreases [1-14C]palmitate oxidation to 14CO2 and is associated with an increased [hydroxybutyrate]/[acetoacetate] ratio. 8. These results are discussed with reference to the control of gluconeogenesis in various species.
摘要
- 色氨酸对离体大鼠肝细胞糖异生的抑制作用表现为在达到葡萄糖输出的线性速率之前有20分钟的延迟期。2. 约0.1 mM色氨酸可使离体大鼠肝细胞的糖异生受到半数最大抑制。3. 色氨酸抑制由所有生成草酰乙酸的底物进行的糖异生，但刺激以甘油为燃料的葡萄糖生成。4. 豚鼠肝细胞的糖异生对色氨酸不敏感。5. 大鼠肝细胞中代谢物浓度的变化与磷酸烯醇式丙酮酸羧激酶催化步骤处的抑制位点一致。6. 用色氨酸对大鼠进行体内预处理后，其肝细胞中的糖异生抑制作用仍然存在。7. 色氨酸对丙氨酸生成尿素没有影响，但可使[1-14C]棕榈酸氧化为14CO2的量减少，并与[羟丁酸]/[乙酰乙酸]比值增加有关。8. 参照不同物种糖异生的调控对这些结果进行了讨论。
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