色氨酸吡咯酶活性增强可能参与了皮质酮和饥饿诱导的大鼠肝脏中烟酰胺腺嘌呤二核苷酸（磷酸）浓度升高的过程。
Possible involvement of the enhanced tryptophan pyrrolase activity in the corticosterone- and starvation-induced increases in concentrations of nicotinamide-adenine dinucleotides (phosphates) in rat liver.
作者信息
Badawy A A
出版信息
Biochem J. 1981 Apr 15;196(1):217-24. doi: 10.1042/bj1960217.
Abstract
- Deoxycorticosterone, which does not enhance tryptophan pyrrolase activity, also fails to alter the concentrations of the NAD(P) couples in livers of fed rats, whereas corticosterone increases both pyrrolase activity and dinucleotide concentrations. 2. Starvation of rats increases serum corticosterone concentration, lipolysis, tryptophan availability to the liver, tryptophan pyrrolase activity and liver [NADP(H)]. Glucose prevents all these changes. 3. The beta-adrenoceptor-blocking agent propranolol prevents the starvation-induced lipolysis and the consequent increase in tryptophan availability to the liver, but does not influence the increase in serum corticosterone concentration, liver pyrrolase activity and [NADP(H)]. 4. Actinomycin D, which prevents the starvation-induced increases in liver pyrrolase activity and [NADP(H)], does not affect those in serum corticosterone concentration and tryptophan availability to the liver. 5. Allopurinol, which blocks the starvation-induced enhancement of pyrrolase activity, also abolishes the increases in liver [NADP(H)], but not those in serum corticosterone concentration or tryptophan availability to the liver. 6. It is suggested that liver tryptophan pyrrolase activity plays an important role in NAD+ synthesis from tryptophan in the rat.
摘要
- 脱氧皮质酮不能增强色氨酸吡咯酶的活性，也不能改变喂食大鼠肝脏中NAD(P)偶联物的浓度，而皮质酮则能增加吡咯酶活性和二核苷酸浓度。2. 饥饿会使大鼠血清皮质酮浓度升高，并增加脂肪分解、肝脏对色氨酸的摄取、色氨酸吡咯酶活性以及肝脏中的[NADP(H)]。葡萄糖可防止所有这些变化。3. β-肾上腺素能受体阻滞剂普萘洛尔可防止饥饿诱导的脂肪分解以及随之而来的肝脏对色氨酸摄取的增加，但不影响血清皮质酮浓度、肝脏吡咯酶活性和[NADP(H)]的升高。4. 放线菌素D可防止饥饿诱导的肝脏吡咯酶活性和[NADP(H)]的升高，但不影响血清皮质酮浓度和肝脏对色氨酸摄取的升高。5. 别嘌呤醇可阻断饥饿诱导的吡咯酶活性增强，也可消除肝脏中[NADP(H)]的升高，但不影响血清皮质酮浓度或肝脏对色氨酸摄取的升高。6. 提示肝脏色氨酸吡咯酶活性在大鼠从色氨酸合成NAD⁺的过程中起重要作用。
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1
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Endocrinology. 1964 Apr;74:653-5. doi: 10.1210/endo-74-4-653.
2
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J Nutr. 1963 Aug;80:441-6. doi: 10.1093/jn/80.4.441.
3
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J Biol Chem. 1963 Apr;238:1548-51.
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8
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10
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