Petrovskaya V G, Bondarenko V M
N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow.
Mol Gen Mikrobiol Virusol. 1995 Apr-Jun(2):15-7.
Data on the genetic basis of the classification of Shigella flexneri serological variants 1-5 are presented. Subserovars "a" are related to monolysogenic variants of the basic lipopolysaccharide (LPS) structure 0 antigen 3,4, "b" to bilysogenic ones. A scheme of their antigenic variability, with regard to loss of one or both prophages is presented. This scheme helps differentiate between antigenic variability and mixed or superinfections. Recent reports confirming our previously published suggestion to exclude serovar 6 (Shigella newcastle) from Shigella flexneri are analyzed. We propose that antigenic variability of S. flexneri 1-5 results from lysogenization of naturally occurring strains. The possibility of consecutive lysogenization of S. flexneri y (-:3,4) by bacteriophages 6 and 7 has been shown, as exemplified by the circulation of a previously unknown subserovar IV:7,8.
本文介绍了福氏志贺氏菌血清变种1 - 5分类的遗传基础数据。亚血清型“a”与基本脂多糖（LPS）结构0抗原3,4的单溶原变种有关，“b”与双溶原变种有关。文中给出了它们抗原变异性的示意图，涉及一个或两个前噬菌体的丢失情况。该示意图有助于区分抗原变异性与混合感染或超感染。分析了近期的报告，这些报告证实了我们之前发表的关于将血清型6（纽卡斯尔志贺氏菌）从福氏志贺氏菌中排除的建议。我们提出福氏志贺氏菌1 - 5的抗原变异性是由自然发生菌株的溶原化引起的。已证明福氏志贺氏菌y（-:3,4）可被噬菌体6和7连续溶原化，例如之前未知的亚血清型IV:7,8的传播就是例证。
