福氏志贺氏菌抗原变异机制。III. 福氏志贺氏菌1b菌株及其作为Lac+重组体或噬菌体F2抗性突变体选择的3b变体的补体敏感性

Mechanism of antigenic variation in Shigella flexneri bacilli. III. Complement sensitivity of S. flexneri 1b strains and their 3b variants selected either as Lac+ recombinants or phage F2 resistant mutants.

作者信息

Doroszkiewicz W, Kopociński B, Lachowicz T M

机构信息

Institute of Microbiology, Wrocław University, Poland.

出版信息

Arch Immunol Ther Exp (Warsz). 1995;43(1):67-72.

Abstract

Several S. flexneri 1b serotype strains of clinical isolation were compared with their 3b serotype variants isolated either as Lac+ recombinants from crosses of S. flexneri x E. coli Hfr C, or F2-resistant mutants. The studied variants 3b were deprived of type I antigen but acquired type III antigen. They appeared to be less sensitive to killing action of complement present in normal bovine serum although kinetics of killing and its effectiveness differed between the strains.

摘要

将几株临床分离的福氏志贺菌1b血清型菌株与其3b血清型变体进行了比较，这些变体要么是从福氏志贺菌与大肠杆菌Hfr C杂交中分离得到的Lac+重组体，要么是F2抗性突变体。所研究的3b变体缺乏I型抗原，但获得了III型抗原。它们似乎对正常牛血清中补体的杀伤作用不太敏感，尽管不同菌株之间的杀伤动力学及其有效性有所不同。

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