Michel M C, Kenny B, Schwinn D A
Department of Medicine, University of Essen, Germany.
Naunyn Schmiedebergs Arch Pharmacol. 1995 Jul;352(1):1-10. doi: 10.1007/BF00169183.
Two alpha 1-adrenoceptor subtypes (alpha 1A and alpha 1B) have been detected in various tissues by pharmacological techniques, and three distinct cDNAs encoding alpha 1-adrenoceptor subtypes have been cloned. The profile of an increasing number of subtype-selective compounds at cloned and endogenous receptors recently has facilitated alignment between cloned and pharmacologically defined alpha 1-adrenoceptor subtypes. Thus, alpha 1a-adrenoceptors (previously designated alpha 1c), alpha 1b-adrenoceptors and alpha 1d-adrenoceptors (previously designated alpha 1a, alpha 1d or alpha 1a/d) are now recognized. Since the alpha 1d-adrenoceptor shares characteristics with both alpha 1A- and alpha 1B-adrenoceptors, tissues previously reported to express alpha 1A- and/or alpha 1B-adrenoceptors may additionally contain alpha 1d-adrenoceptors. This article reviews the features of all three subtypes and discusses possible pitfalls in their pharmacological identification.
通过药理学技术已在多种组织中检测到两种α1肾上腺素能受体亚型（α1A和α1B），并且已克隆出三种编码α1肾上腺素能受体亚型的不同cDNA。最近，越来越多的亚型选择性化合物在克隆受体和内源性受体上的作用情况，促进了克隆的与药理学定义的α1肾上腺素能受体亚型之间的对应。因此，现在已识别出α1a-肾上腺素能受体（以前称为α1c）、α1b-肾上腺素能受体和α1d-肾上腺素能受体（以前称为α1a、α1d或α1a/d）。由于α1d-肾上腺素能受体兼具α1A-和α1B-肾上腺素能受体的特征，以前报道表达α1A-和/或α1B-肾上腺素能受体的组织可能还含有α1d-肾上腺素能受体。本文综述了所有三种亚型的特征，并讨论了其药理学鉴定中可能存在的问题。
