DeSanto N G, Anastasio P, Loguercio C, Spitali L, Del Vecchio Blanco C, Corvinelli M, Cirillo M
Department of Pediatrics, Seconda Università degli Studi, Naples, Italy.
Nephron. 1995;70(4):421-4. doi: 10.1159/000188639.
Glomerular filtration rate (GFR) was measured in 19 patients with Child A liver cirrhosis by comparing the endogenous creatinine clearance with inulin clearance. Inulin clearance averaged 90 +/- 4.4 ml/min x 1.73 m2, while creatinine clearance averaged 122 +/- 7 ml/min x 1.73 m2 (p < 0.001). The overestimation of GFR by creatinine was present in 18 of 19 patients and was inversely correlated with inulin clearance (r = -0.452, p < 0.04). The data point to the unsuitability of creatinine as a marker of filtration in early posthepatitic cirrhosis (Child A).
通过比较内源性肌酐清除率和菊粉清除率，对19例Child A级肝硬化患者的肾小球滤过率（GFR）进行了测量。菊粉清除率平均为90±4.4 ml/min×1.73 m²，而肌酐清除率平均为122±7 ml/min×1.73 m²（p<0.001）。19例患者中有18例存在肌酐对GFR的高估，且与菊粉清除率呈负相关（r = -0.452，p<0.04）。这些数据表明肌酐不适用于作为肝炎后早期肝硬化（Child A级）滤过的标志物。
