Stotz-Potter E H, Ghetti B, Simon J R
Department of Psychiatry (Institute of Psychiatric Research), Indiana University School of Medicine, Indianapolis 46202-4887, USA.
Neurochem Res. 1995 Jul;20(7):821-6. doi: 10.1007/BF00969694.
In addition to an altered dopaminergic input, the striatum of the weaver mutant mouse (wv/wv) has increased serotonin tissue content and uptake compared to the wild-type mouse (+/+). To gain information regarding the functional status of serotonergic inputs to the wv/wv striatum, endogenous serotonin release from wv/wv and +/+ striatum was measured under basal conditions as well as in the presence of fenfluramine or elevated concentrations of potassium (K+). Fractional basal release of serotonin from the +/+ striatum was significantly greater than that from the wv/wv striatum. In the presence of K+, evoked release (stimulated release minus basal release) was greater from the +/+ striatum than from the wv/wv striatum. In the presence of fenfluramine, evoked serotonin release was greater from the wv/wv striatum compared to the +/+ striatum. These data are consistent with the involvement of an additional transmitter(s) in modulating serotonin release to a greater extent in the wv/wv than the +/+ striatum. The data on fenfluramine-stimulated serotonin release suggest that the additional serotonin content found in the wv/wv striatum is in a releasable pool but that striatal serotonin release might be attenuated more in wv/wv than in +/+ mice.
除了多巴胺能输入改变外，与野生型小鼠（+/+）相比，织工突变小鼠（wv/wv）的纹状体中5-羟色胺组织含量和摄取增加。为了获取有关wv/wv纹状体中5-羟色胺能输入功能状态的信息，在基础条件下以及在芬氟拉明或高浓度钾（K+）存在的情况下，测量了wv/wv和+/+纹状体中内源性5-羟色胺的释放。来自+/+纹状体的5-羟色胺基础释放分数显著高于来自wv/wv纹状体的释放分数。在K+存在的情况下，+/+纹状体的诱发释放（刺激释放减去基础释放）大于wv/wv纹状体。在芬氟拉明存在的情况下，与+/+纹状体相比，wv/wv纹状体的诱发5-羟色胺释放更大。这些数据与一种或多种额外递质在更大程度上调节wv/wv纹状体而非+/+纹状体中5-羟色胺释放的参与情况一致。关于芬氟拉明刺激的5-羟色胺释放的数据表明，在wv/wv纹状体中发现的额外5-羟色胺含量处于可释放池中，但wv/wv小鼠纹状体中的5-羟色胺释放可能比+/+小鼠更易减弱。
