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[一例桥小脑角表皮样癌的病例报告]

[A case report of epidermoid carcinoma in the cerebello-pontine angle].

作者信息

Mori Y, Suzuki Y, Tanasawa T, Yoshida J, Wakabayashi T, Kobayashi T

机构信息

Department of Neurosurgery, Nagoya University School of Medicine.

出版信息

No Shinkei Geka. 1995 Oct;23(10):905-9.

PMID:7477700
Abstract

A case of epidermoid carcinoma in the cerebello-pontine (CP) angle is presented. A 42-year-old male was admitted with a complaint of experiencing double vision for four months in January, 1992. During neurological examination, right abducens palsy, right facial dysesthesia, and atrophy of the right temporal muscle were noted. Magnetic resonance (MR) imaging revealed a mass of low intensity in the right CP angle, which was prominently enhanced with gadolinium. Malignancy was suspected because the tumor on MR enlarged rapidly in a month, so the first surgical resection was performed. Suboccipital exploration of the right CP angle was performed in February. At first, a fragile, pearly part of the mass typical of epidermoid was exposed behind the seventh and eighth cranial nerve complex. Then, a grayish, fibrous part was exposed, which involved the fifth cranial nerve and was attached to the tentorium and the brainstem. Histological diagnosis of the fragile part of the tumor revealed a typical epidermoid cyst and that of the fibrous part was squamous cell carcinoma. During postoperative examinations on other parts of the body, such as endoscopic studies of the trachea and the esophagus, no abnormality was shown. Therefore the tumor was diagnosed as a primary intracranial epidermoid carcinoma. Post-operatively, conventional fractionated external-beam focal irradiation was carried out, which caused regression of the residual tumor for eleven months. Subsequently, palsy of the right side of the tongue and paresis of the contralateral side of the extremities and face developed with increase of the right abducens palsy. MR imaging indicated regrowth of the tumor. The second operation via the subtemporal approach was unsuccessful, because the tumor was fibrous and firmly attached to the brainstem.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

本文报告一例桥小脑角表皮样癌。1992年1月,一名42岁男性因双眼复视4个月入院。神经系统检查发现右侧展神经麻痹、右侧面部感觉异常和右侧颞肌萎缩。磁共振成像显示右侧桥小脑角有一低信号肿块,钆增强明显。由于磁共振成像上肿瘤在1个月内迅速增大,怀疑为恶性,因此进行了首次手术切除。2月对右侧桥小脑角进行枕下探查。起初,在第七和第八脑神经复合体后方暴露了一个脆弱的、珍珠样的典型表皮样肿块部分。然后,暴露了一个灰白色的纤维部分,该部分累及第五脑神经,并附着于小脑幕和脑干。肿瘤脆弱部分的组织学诊断为典型的表皮样囊肿,纤维部分为鳞状细胞癌。在对身体其他部位进行术后检查时,如气管和食管的内镜检查,未发现异常。因此,该肿瘤被诊断为原发性颅内表皮样癌。术后进行了常规分割外照射局部放疗,使残留肿瘤消退了11个月。随后,随着右侧展神经麻痹加重,出现右侧舌瘫和对侧肢体及面部轻瘫。磁共振成像显示肿瘤复发。经颞下途径进行的第二次手术未成功,因为肿瘤质地坚韧,与脑干紧密相连。(摘要截短至250字)

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