Lazzaretti M G, Zenezini Chiozzi A, Bernardelli D, Castellani Tarabini C, Gavioli M, Piccagli I, Rosi A, Biagini M, Romani M
IV Divisione di Chirurgia Generale Ospedale di Castelfranco Emilia, U.S.L. n. 16, Modena.
Minerva Ginecol. 1995 May;47(5):197-205.
The Authors have studied the effects of different surgical interventions on some factors of humoral and cell-mediated immuno-competence: 112 premenopausal women, operated on mainly for benign conditions, have been considered in order to evaluate the influence of various phases of menstrual cycle on surgical immunosuppression. Two schemes were used to stratify the study sample: in the first analysis, we have subdivided the patients in 59 cases in perimenstrual phase (0 through 6 and 21 through 36 days from last menstrual period, LMP) and 53 in periovulatory (7-20 days from LMP). The second stratification relied on the hormone-dependent phases determined by the putative time of ovulation 14 days after LMP: 51 cases in follicular phase and 61 cases in luteal phase have been considered. Immune parameters have been evaluated before surgery and the day after intervention. The first comparison stresses the worst outcome of immune parameters in patients operated on in the perimenstrual period (CD4, activated lymphocytes and C3 have significantly reduced post-operatively). The second part of the study shows no significant difference in the two groups as to such parametres.
为了评估月经周期各阶段对手术免疫抑制的影响，对112名主要因良性疾病接受手术的绝经前女性进行了研究。采用两种方案对研究样本进行分层：在第一次分析中，我们将患者分为59例处于围经期（距末次月经第一天LMP的0至6天和21至36天）和53例处于排卵期（距LMP的7至20天）。第二次分层依据假定排卵时间（LMP后14天）确定的激素依赖期：考虑了51例处于卵泡期和61例处于黄体期的病例。在手术前和干预后一天评估免疫参数。第一次比较强调了围经期手术患者免疫参数的最差结果（术后CD4、活化淋巴细胞和C3显著降低）。研究的第二部分表明，两组在这些参数方面没有显著差异。
