Doerfler D L, Nulton C P, Bartman C D, Gottlieb F J, Campbell I M
Can J Microbiol. 1978 Dec;24(12):1490-501. doi: 10.1139/m78-239.
A study of the first 76 h of development of spores of Penicillium brevicompactum in batch-mode shake culture indicates that mycophenolic acid biosynthesis begins when the hyphae of germinating spores aggregate to form pellets. Supplies of mycophenolic acid so produced augment a pre-existing pool of the material that is associated with the dormant spore. Although acetate metabolism is active at all stages of development, incorporation of [1-(14)C]acetate into 2,4-dihydroxy-6-(1',2'-dioxopropyl)benzoic acid, another secondary metabolite of the fungus, could not be demonstrated. The significance of these data are considered in terms of the function of mycophenolic acid and the substituted benzoic acid in the producing organism.
一项关于短密青霉孢子在分批模式摇瓶培养中前76小时发育的研究表明，霉酚酸生物合成始于萌发孢子的菌丝聚集形成小球时。如此产生的霉酚酸供应增加了与休眠孢子相关的该物质的预先存在的库。尽管乙酸代谢在发育的所有阶段都很活跃，但无法证明[1-(14)C]乙酸掺入该真菌的另一种次生代谢产物2,4-二羟基-6-(1',2'-二氧代丙基)苯甲酸中。从霉酚酸和取代苯甲酸在产生生物体中的功能方面考虑了这些数据的意义。
