Reeve A J, Dickenson A H
Department of Pharmacology, University College London, UK.
Neurosci Lett. 1995 Jul 14;194(1-2):81-4. doi: 10.1016/0304-3940(95)11732-c.
The effects of intrathecal N6-cyclopentyladenosine (N6-CPA), an A1-receptor agonist, and morphine, a mu opioid-receptor agonist were studied on the electrically evoked responses of deep dorsal horn neurones in the rat. Both caused inhibitions, when applied alone, of the C-fibre evoked response and post-discharges. Enhanced inhibitory effects were observed when N6-CPA (5 micrograms) was given with morphine (1 microgram). Increasing the dose of morphine (5 micrograms) with the same dose of N6-CPA occluded the expected inhibitions. By contrast, the A delta-fibre evoked response, inhibited by morphine alone, was significantly facilitated by the combination. Parallel activation of purinergic and opioid inhibitory systems within the dorsal horn as well as complex interactions between them are likely.
研究了鞘内注射A1受体激动剂N6-环戊基腺苷（N6-CPA）和μ阿片受体激动剂吗啡对大鼠脊髓背角深层神经元电诱发反应的影响。单独应用时，二者均可抑制C纤维诱发反应和后放电。当给予N6-CPA（5微克）和吗啡（1微克）时，观察到增强的抑制作用。用相同剂量的N6-CPA增加吗啡剂量（5微克）可消除预期的抑制作用。相比之下，单独被吗啡抑制的Aδ纤维诱发反应在二者联合应用时得到显著易化。背角内嘌呤能和阿片样物质抑制系统的平行激活以及它们之间的复杂相互作用是可能的。
