D-20443对遗传性癫痫易感性大鼠的抗惊厥特性：临床反应预测
Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: prediction of clinical response.
作者信息
Dailey J W, Cheong J H, Ko K H, Adams-Curtis L E, Jobe P C
机构信息
Department of Basic Sciences, University of Illinois College of Medicine at Peoria 61656, USA.
出版信息
Neurosci Lett. 1995 Aug 4;195(2):77-80. doi: 10.1016/0304-3940(95)11783-s.
D-20443 is an experimental antiepileptic drug. Its mechanism of antiepileptic action is unknown. We evaluated the anticonvulsant effectiveness of D-20443 against sound-induced seizures in genetically epilepsy-prone rats (GEPRs). This compound produced anticonvulsant effects against sound-induced seizures in moderate seizure GEPRs (GEPR-3s) at significantly lower doses than in severe seizure GEPRs (GEPR-9s). Based on these data and on the responses of GEPRs to other antiepileptic drugs, we predict that D-20443 will be a broad spectrum antiepileptic agent in humans. That is, we predict that D-20443 will suppress both tonic/clonic and absence seizures in humans.
D - 20443是一种实验性抗癫痫药物。其抗癫痫作用机制尚不清楚。我们评估了D - 20443对遗传性癫痫易感大鼠（GEPRs）声音诱发癫痫发作的抗惊厥效果。该化合物在中度癫痫发作的GEPRs（GEPR - 3s）中，对声音诱发的癫痫发作产生抗惊厥作用的剂量显著低于重度癫痫发作的GEPRs（GEPR - 9s）。基于这些数据以及GEPRs对其他抗癫痫药物的反应，我们预测D - 20443在人类中将是一种广谱抗癫痫药物。也就是说，我们预测D - 20443将抑制人类的强直/阵挛性发作和失神发作。
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