Gutiérrez R, Boison D, Heinemann U, Stoffel W
Institut für Biochemie, Universität zu Köln, Germany.
Neurosci Lett. 1995 Aug 4;195(2):93-6. doi: 10.1016/0304-3940(94)11789-l.
The conduction velocity of action potentials in nerve fibres is proportional to degree of myelination. Here we studied the influence of myelin ultrastructure on the compound action potential conduction velocity in optic nerves of the proteolipid protein (PLP)-deficient mouse model, which displays loose myelination in central fibres. We show that a myelin decompaction leads to a suboptimal conduction velocity. The significance of myelin ultrastructure for conduction of action potential in the optic nerve is discussed.
神经纤维中动作电位的传导速度与髓鞘形成程度成正比。在此，我们研究了髓鞘超微结构对脂蛋白（PLP）缺陷小鼠模型视神经中复合动作电位传导速度的影响，该模型在中枢神经纤维中表现出髓鞘疏松。我们发现髓鞘松解会导致传导速度不理想。文中讨论了髓鞘超微结构对视神经中动作电位传导的意义。
