Haller Olivia C, Rosenberg Cassandra L, King Tricia Z
Department of Psychology, Georgia State University, Atlanta, GA, USA.
Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
Neuropsychol Rev. 2025 Aug 7. doi: 10.1007/s11065-025-09671-9.
Dynamic functional connectivity (dFC) methods could shift understandings about brain-behavior relationships. Information processing speed (IPS) may be of particular interest to dFC analyses as dFC is able to capture time-sensitive FC changes. The present systematic review aims to explore the association between IPS and dFC of resting-state functional magnetic resonance imaging (rsfMRI) data in healthy individuals. Included papers were published through July 24, 2023. Searches conducted on ProQuest and ScienceDirect used the search terms processing speed AND fMRI AND resting state AND dynamic functional connectivity OR dynamic functional network connectivity. Studies were eligible based on the following inclusion criteria: empirical research, published in English, use of a well-characterized healthy population (n > 30), use of rsfMRI, calculation of dFC, measurement of IPS, and a statistical test between dFC and IPS. Results reveal mixed findings. Five studies report no relationship between dFC and IPS, whereas eight report mixed or positive findings. We noted several trends in findings that may be driving inconsistencies. Over half of the reviewed studies used the Human Connectome Project data. Second, IPS was more likely to be related to dFC if images were acquired using an eyes open procedure with fixation on a crosshair. As all included IPS measures involved a visual component, IPS and dFC measurement might both be capturing information about visuoperceptual connections. Future work that addresses these biases and trends may illuminate the nature of the relationship between dFC and IPS.
动态功能连接（dFC）方法可能会改变人们对脑-行为关系的理解。信息处理速度（IPS）可能是dFC分析特别感兴趣的内容，因为dFC能够捕捉对时间敏感的功能连接（FC）变化。本系统综述旨在探讨健康个体静息态功能磁共振成像（rsfMRI）数据中IPS与dFC之间的关联。纳入的论文发表截至2023年7月24日。在ProQuest和ScienceDirect上进行的搜索使用了搜索词“处理速度”“功能磁共振成像”“静息态”“动态功能连接”或“动态功能网络连接”。基于以下纳入标准，研究具有资格：实证研究、以英文发表、使用特征明确的健康人群（n>30）、使用rsfMRI、计算dFC、测量IPS以及dFC与IPS之间的统计检验。结果显示出混合的发现。五项研究报告dFC与IPS之间没有关系，而八项研究报告了混合或阳性结果。我们注意到一些可能导致不一致的发现趋势。超过一半的综述研究使用了人类连接组计划的数据。其次，如果图像是在睁眼并注视十字准线的程序下采集的，IPS更有可能与dFC相关。由于所有纳入的IPS测量都涉及视觉成分，IPS和dFC测量可能都在捕捉有关视觉感知连接的信息。解决这些偏差和趋势的未来工作可能会阐明dFC与IPS之间关系的本质。
