Is an elevated circulating maternal homocysteine concentration a risk factor for neural tube defects?
作者信息
Ubbink J B
机构信息
Department of Chemical Pathology, University of Pretoria, South Africa.
出版信息
Nutr Rev. 1995 Jun;53(6):173-5. doi: 10.1111/j.1753-4887.1995.tb01546.x.
Abstract
The mechanism by which folic acid supplementation reduces neural tube defect (NTD) incidence is unknown. Recent evidence suggests that mothers with NTD neonates have higher circulating homocysteine concentrations compared with controls. This presumably indicates impaired homocysteine remethylation, resulting in a possible methionine shortage at a crucial stage of fetal development.
摘要
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