Onyemelukwe Obiageli Uzoamaka, Maiha Bilkisu Bello
Department of Medicine, Ahmadu Bello University Teaching Hospital; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
Ann Afr Med. 2019 Jul-Sep;18(3):143-152. doi: 10.4103/aam.aam_53_18.
This study aimed to determine the prevalence of hyperhomocysteinemia and folate status in a sample of normal healthy Nigerians living in Zaria as well as assess the relationship between homocysteine, folate, and blood pressure (BP) levels.
It was a cross-sectional analytical study carried out among 65 normal healthy volunteers aged 18-65 years. Participants were randomly selected from willing patient escorts, hospital employees, and willing staff presenting at the Ahmadu Bello University Medical Centre, Zaria and Ahmadu Bello University Teaching Hospital, Zaria, Nigeria. The percentage of participants who had high homocysteine levels as well as their plasma folate status was determined.
There were 9.2% with hyperhomocysteinemia >15 μmol/L and 51% with hyperhomocysteinemia >10 μmol/L. The mean plasma homocysteine level was 10.8 ± 2.7 μmol/L with male and female values of 10.7 ± 2.6 and 10.8 ± 2.8, respectively (P = 0.87). The mean plasma folate level was high (116.7 ± 44.0 ng/mL) with male value of (111.5 ± 44.9 ng/mL) which did not differ significantly (P = 0.37) from that of females (121.4 ± 43.3 ng/mL). Homocysteine showed a positive significant (P = 0.01) relationship with folate but not with BP's (P > 0.05).
There is a high prevalence of hyperhomocysteinemia in normal healthy Northern-Nigerians which cannot be accounted for by suboptimal folate levels. Hyperhomocysteinemia may not be a risk factor for cardiovascular disease in normal healthy Nigerians despite its high levels as it showed no significant relationship with BP.
本研究旨在确定居住在扎里亚的正常健康尼日利亚人群样本中高同型半胱氨酸血症的患病率和叶酸状况，并评估同型半胱氨酸、叶酸与血压（BP）水平之间的关系。
这是一项对65名年龄在18 - 65岁的正常健康志愿者进行的横断面分析研究。参与者是从愿意陪同患者的人员、医院员工以及在尼日利亚扎里亚的阿哈穆杜·贝洛大学医学中心和阿哈穆杜·贝洛大学教学医院就诊的自愿工作人员中随机选取的。测定了高同型半胱氨酸水平的参与者百分比及其血浆叶酸状况。
同型半胱氨酸血症>15 μmol/L的患者占9.2%，同型半胱氨酸血症>10 μmol/L的患者占51%。血浆同型半胱氨酸平均水平为10.8±2.7 μmol/L，男性和女性的值分别为10.7±2.6和10.8±2.8（P = 0.87）。血浆叶酸平均水平较高（116.7±44.0 ng/mL），男性值为（111.5±44.9 ng/mL），与女性（121.4±43.3 ng/mL）相比无显著差异（P = 0.37）。同型半胱氨酸与叶酸呈显著正相关（P = 0.01），但与血压无相关性（P>0.05）。
在正常健康的尼日利亚北部人群中，高同型半胱氨酸血症患病率较高，这不能用叶酸水平欠佳来解释。尽管同型半胱氨酸水平较高，但在正常健康的尼日利亚人中，高同型半胱氨酸血症可能不是心血管疾病的危险因素，因为它与血压无显著关系。
